|
|
 Previous Article | Table of Contents | Next Article 
Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor
signaling for human immunodeficiency virus production in chronically
infected HL-60 cells
CI Rivas, DW Golde, JC Vera and RN Kolesnick
Program in Molecular Pharmacology and Therapeutics, Memorial Sloan-
Kettering Cancer Center, New York, NY 10021.
Tumor necrosis factor (TNF) is a potent inducer of human immunodeficiency
virus (HIV) proviral transcription and subsequent mature virus production.
Recent investigations have shown that TNF can use a signal transduction
pathway in HL-60 cells involving sphingomyelin hydrolysis to ceramide with
subsequent stimulation of a ceramide-linked kinase. When sphingomyelinase
was added exogenously to activate this cascade in HIV-1-infected HL-60
cells, it mimicked TNF- induced HIV production. Phospholipases A2, C, or D,
which do not generate ceramide, had no effect; however, a synthetic
ceramide analog added exogenously potently induced HIV production. In
addition, anti- TNF antibodies blocked much of the effect of both
sphingomyelinase and the synthetic ceramide analog on virus expression,
suggesting that, although signaling is initiated through the sphingomyelin
pathway, it is sustained by autocrine TNF synthesis. Thus, direct
activation of the sphingomyelin pathway recapitulated the effect of TNF on
both HIV and TNF production. These studies indicate that the sphingomyelin
pathway is involved in TNF signaling for HIV production in chronically
infected myeloid cells.
Volume 83,
Issue 8,
pp. 2191-2197,
04/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
I Petrache, K Diab, K S Knox, H L Twigg III, R S Stephens, S Flores, and R M Tuder
HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism
Thorax,
May 1, 2008;
63(5):
463 - 469.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. W. Yeh, M. Kaul, J. Zheng, H. S. L. M. Nottet, M. Thylin, H. E. Gendelman, and S. A. Lipton
Cytokine-Stimulated, But Not HIV-Infected, Human Monocyte-Derived Macrophages Produce Neurotoxic Levels of L-Cysteine
J. Immunol.,
April 15, 2000;
164(8):
4265 - 4270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sol, J. Le Junter, I. Vassias, J. M. Freyssinier, A. Thomas, A. F. Prigent, B. B. Rudkin, S. Fichelson, and F. Morinet
Possible Interactions between the NS-1 Protein and Tumor Necrosis Factor Alpha Pathways in Erythroid Cell Apoptosis Induced by Human Parvovirus B19
J. Virol.,
October 1, 1999;
73(10):
8762 - 8770.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Moretti, E. Alesse, L. Di Marzio, F. Zazzeroni, B. Ruggeri, S. Marcellini, G. Famularo, S. M. Steinberg, A. Boschini, M. G. Cifone, et al.
Effect of L-Carnitine on Human Immunodeficiency Virus-1 Infection-Associated Apoptosis: A Pilot Study
Blood,
May 15, 1998;
91(10):
3817 - 3824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Allan-Yorke, M. Record, C. de Preval, C. Davrinche, and J.-L. Davignon
Distinct Pathways for Tumor Necrosis Factor Alpha and Ceramides in Human Cytomegalovirus Infection
J. Virol.,
March 1, 1998;
72(3):
2316 - 2322.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Andrieu, R. Salvayre, J.-P. Jaffrézou, and T. Levade
Low Temperatures and Hypertonicity Do Not Block Cytokine-induced Stimulation of the Sphingomyelin Pathway but Inhibit Nuclear Factor-kappaB Activation
J. Biol. Chem.,
October 13, 1995;
270(41):
24518 - 24524.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
