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The human myeloid cell nuclear differentiation antigen gene is one of at
least two related interferon-inducible genes located on chromosome 1q that
are expressed specifically in hematopoietic cells
RC Briggs, JA Briggs, J Ozer, L Sealy, LL Dworkin, SF Kingsmore, MF Seldin, GP Kaur, RS Athwal and EN Dessypris
Department of Pathology, Vanderbilt University, Nashville, TN 37232.
We have previously shown that the human myeloid cell nuclear
differentiation antigen (MNDA) is expressed at both the antigen and mRNA
levels specifically in human monocytes and granulocytes and earlier stage
cells in the myeloid lineage. A 200 amino acid region of the MNDA is
strikingly similar to a region in the proteins encoded by a family of
interferon-inducible mouse genes, designated Ifi-201, Ifi- 202, Ifi-203,
etc, that are not regulated in a cell- or tissue-specific fashion. However,
a new member of the Ifi-200 gene family, D3, is induced in mouse
mononuclear phagocytes but not in fibroblasts by interferon. The same 200
amino acid region, duplicated in the mouse Ifi- 200 gene family, is also
repeated in the recently characterized human IFI 16 gene that is
constitutively expressed specifically in lymphoid cells and is induced in
myeloid cells by interferon gamma. The 1.8-kb MNDA mRNA, which contains an
interferon-stimulated response element in the 5' untranslated region, was
significantly upregulated in human monocytes exposed to interferon alpha.
Characterization of the MNDA gene showed that it is a single-copy gene and
localized to human chromosome 1q 21-22 within the large linkage group
conserved between mouse and human that contains the Ifi-200 gene family.
The IFI 16 gene is also located on human chromosome 1q. Our observations
are consistent with the proposal that the MNDA is a member of a cluster of
related human interferon-regulated genes, similar to the mouse Ifi-200 gene
family. In addition, one mouse gene in the Ifi-200 gene family and the
human MNDA and IFI 16 genes show expression and/or regulation restricted to
cells of the hematopoietic system, suggesting that these genes participate
in blood cell-specific responses to interferons.
Volume 83,
Issue 8,
pp. 2153-2162,
04/15/1994
Copyright © 1994 by The American Society of Hematology
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