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A human homologue of the Drosophila developmental gene, Notch, is expressed
in CD34+ hematopoietic precursors
LA Milner, R Kopan, DI Martin and ID Bernstein
Pediatric Oncology Program, Fred Hutchinson Cancer Research Center,
Seattle, WA 98109.
Members of the Notch gene family have been shown to mediate cell-fate
decisions by multipotent precursors in a number of different systems. To
determine whether members of this family might play a similar role in
hematopoiesis, we asked if homologues of the Notch gene are expressed in
human hematopoietic precursors. Using degenerate oligonucleotides
corresponding to conserved amino acid sequences in known Notch homologues
as primers for the polymerase chain reaction (PCR), we demonstrated that at
least one Notch homologue is expressed in human bone marrow CD34+ cells, a
population enriched for hematopoietic precursors. Cloning and sequencing of
the PCR products identified this Notch homologue as TAN-1, a member of the
Notch family previously cloned from a T-cell leukemia with a translocation
involving this gene. Subsequent evaluation of bone marrow hematopoietic
cells for TAN-1 expression using a reverse transcription-PCR assay
confirmed the expression of TAN-1 in CD34+ hematopoietic precursors,
including the immature subset that lacks expression of lineage-associated
antigens (CD34+lin-). These findings, together with the known role of Notch
homologues in other systems, suggest that members of the Notch family,
including TAN-1, may be involved in mediating cell-fate decisions during
hematopoiesis.
Volume 83,
Issue 8,
pp. 2057-2062,
04/15/1994
Copyright © 1994 by The American Society of Hematology
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