|
|
 Previous Article | Table of Contents | Next Article 
Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia
A Bedi, BA Zehnbauer, JP Barber, SJ Sharkis and RJ Jones
Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions,
Baltimore, MD 21287-8967.
BCR-ABL expression is presumed to effect clonal expansion in chronic
myeloid leukemia (CML) by deregulation of cell proliferation. However, most
studies have found that relative rates of cell proliferation are not
increased in CML. Moreover, we found that CML progenitors display a normal
proliferative response to growth factors and do not manifest greater
proliferative potential than normal progenitors. Growth of malignancies
depends on an imbalance between the rate of cell production and the rate of
cell death. We found that BCR-ABL expression inappropriately prolongs the
growth factor-independent survival of CML myeloid progenitors and
granulocytes by inhibiting apoptosis, a genetically programmed process of
active cell death; inhibition of BCR- ABL expression by antisense
oligonucleotides reversed the suppression of apoptosis as well as the
enhancement of survival. The decreased rate of programmed cell death
appears to be the primary mechanism by which BCR-ABL effects expansion of
the leukemic clone in CML.
Volume 83,
Issue 8,
pp. 2038-2044,
04/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
Y. Dai, S. Chen, C. A. Venditti, X.-Y. Pei, T. K. Nguyen, P. Dent, and S. Grant
Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate
Blood,
August 1, 2008;
112(3):
793 - 804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Kavalerchik, D. Goff, and C. H.M. Jamieson
Chronic Myeloid Leukemia Stem Cells
J. Clin. Oncol.,
June 10, 2008;
26(17):
2911 - 2915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Copland, F. Pellicano, L. Richmond, E. K. Allan, A. Hamilton, F. Y. Lee, R. Weinmann, and T. L. Holyoake
BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors
Blood,
March 1, 2008;
111(5):
2843 - 2853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mayerhofer, K. V. Gleixner, J. Mayerhofer, G. Hoermann, E. Jaeger, K. J. Aichberger, R. G. Ott, K. Greish, H. Nakamura, S. Derdak, et al.
Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib
Blood,
February 15, 2008;
111(4):
2200 - 2210.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lee, Y. Kim, J. Lim, M. Kim, and K. Han
G-CSF and GM-CSF Concentrations and Receptor Expression in Peripheral Blood Leukemic Cells from Patients with Chronic Myelogenous Leukemia
Ann. Clin. Lab. Sci.,
January 1, 2008;
38(4):
331 - 337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. La Rosee, T. Jia, S. Demehri, N. Hartel, P. de Vries, L. Bonham, D. Hollenback, J. W. Singer, J. V. Melo, B. J. Druker, et al.
Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-{beta} Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib.
Clin. Cancer Res.,
November 1, 2006;
12(21):
6540 - 6546.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Ma, G. Ruan, Y. Wang, Q. Li, P. Zhu, Y.-Z. Qin, J.-L. Li, Y.-R. Liu, D. Ma, and H. Zhao
Two Single-Nucleotide Polymorphisms with Linkage Disequilibrium in the Human Programmed Cell Death 5 Gene 5' Regulatory Region Affect Promoter Activity and the Susceptibility of Chronic Myelogenous Leukemia in Chinese Population
Clin. Cancer Res.,
December 15, 2005;
11(24):
8592 - 8599.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Aichberger, M. Mayerhofer, M.-T. Krauth, A. Vales, R. Kondo, S. Derdak, W. F. Pickl, E. Selzer, M. Deininger, B. J. Druker, et al.
Low-Level Expression of Proapoptotic Bcl-2-Interacting Mediator in Leukemic Cells in Patients with Chronic Myeloid Leukemia: Role of BCR/ABL, Characterization of Underlying Signaling Pathways, and Reexpression by Novel Pharmacologic Compounds
Cancer Res.,
October 15, 2005;
65(20):
9436 - 9444.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. B. Hickey, K. England, and T. G. Cotter
Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK
J. Leukoc. Biol.,
July 1, 2005;
78(1):
289 - 300.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Andreu, E. Lledo, E. Poch, C. Ivorra, M. P. Albero, J. A. Martinez-Climent, C. Montiel-Duarte, J. Rifon, J. Perez-Calvo, C. Arbona, et al.
BCR-ABL Induces the Expression of Skp2 through the PI3K Pathway to Promote p27Kip1 Degradation and Proliferation of Chronic Myelogenous Leukemia Cells
Cancer Res.,
April 15, 2005;
65(8):
3264 - 3272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Aichberger, M. Mayerhofer, M.-T. Krauth, H. Skvara, S. Florian, K. Sonneck, C. Akgul, S. Derdak, W. F. Pickl, V. Wacheck, et al.
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides
Blood,
April 15, 2005;
105(8):
3303 - 3311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Deininger, E. Buchdunger, and B. J. Druker
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
Blood,
April 1, 2005;
105(7):
2640 - 2653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. B. Deming, Z. T. Schafer, J. S. Tashker, M. B. Potts, M. Deshmukh, and S. Kornbluth
Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release
Mol. Cell. Biol.,
December 1, 2004;
24(23):
10289 - 10299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ramaraj, H. Singh, N. Niu, S. Chu, M. Holtz, J. K. Yee, and R. Bhatia
Effect of Mutational Inactivation of Tyrosine Kinase Activity on BCR/ABL-Induced Abnormalities in Cell Growth and Adhesion in Human Hematopoietic Progenitors
Cancer Res.,
August 1, 2004;
64(15):
5322 - 5331.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Ajenjo, E. Canon, I. Sanchez-Perez, D. Matallanas, J. Leon, R. Perona, and P. Crespo
Subcellular Localization Determines the Protective Effects of Activated ERK2 against Distinct Apoptogenic Stimuli in Myeloid Leukemia Cells
J. Biol. Chem.,
July 30, 2004;
279(31):
32813 - 32823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kuribara, H. Honda, H. Matsui, T. Shinjyo, T. Inukai, K. Sugita, S. Nakazawa, H. Hirai, K. Ozawa, and T. Inaba
Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic Progenitors
Mol. Cell. Biol.,
July 15, 2004;
24(14):
6172 - 6183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Calabretta and D. Perrotti
The biology of CML blast crisis
Blood,
June 1, 2004;
103(11):
4010 - 4022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mayerhofer, S. Florian, M.-T. Krauth, K. J. Aichberger, M. Bilban, R. Marculescu, D. Printz, G. Fritsch, O. Wagner, E. Selzer, et al.
Identification of Heme Oxygenase-1 As a Novel BCR/ABL-Dependent Survival Factor in Chronic Myeloid Leukemia
Cancer Res.,
May 1, 2004;
64(9):
3148 - 3154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Matsui, C. A. Huff, Q. Wang, M. T. Malehorn, J. Barber, Y. Tanhehco, B. D. Smith, C. I. Civin, and R. J. Jones
Characterization of clonogenic multiple myeloma cells
Blood,
March 15, 2004;
103(6):
2332 - 2336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. E. Ouriaghli, E. Sloand, L. Mainwaring, H. Fujiwara, K. Keyvanfar, J. J. Melenhorst, K. Rezvani, G. Sconocchia, S. Solomon, N. Hensel, et al.
Clonal dominance of chronic myelogenous leukemia is associated with diminished sensitivity to the antiproliferative effects of neutrophil elastase
Blood,
November 15, 2003;
102(10):
3786 - 3792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Goldman and J. V. Melo
Chronic Myeloid Leukemia -- Advances in Biology and New Approaches to Treatment
N. Engl. J. Med.,
October 9, 2003;
349(15):
1451 - 1464.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. W. N. Deininger and B. J. Druker
Specific Targeted Therapy of Chronic Myelogenous Leukemia with Imatinib
Pharmacol. Rev.,
September 1, 2003;
55(3):
401 - 423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kurzrock, H. M. Kantarjian, B. J. Druker, and M. Talpaz
Philadelphia Chromosome-Positive Leukemias: From Basic Mechanisms to Molecular Therapeutics
Ann Intern Med,
May 20, 2003;
138(10):
819 - 830.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Wong, J. McLaughlin, D. Cheng, and O. N. Witte
Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors
Blood,
May 15, 2003;
101(10):
4088 - 4097.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Roman-Gomez, J. A. Castillejo, A. Jimenez, F. Cervantes, C. Boque, L. Hermosin, A. Leon, A. Granena, D. Colomer, A. Heiniger, et al.
Cadherin-13, a Mediator of Calcium-Dependent Cell-Cell Adhesion, Is Silenced by Methylation in Chronic Myeloid Leukemia and Correlates With Pretreatment Risk Profile and Cytogenetic Response to Interferon Alfa
J. Clin. Oncol.,
April 15, 2003;
21(8):
1472 - 1479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Komatsu, T. Watanabe, M. Uchida, M. Mori, K. Kirito, S. Kikuchi, Q. Liu, T. Tauchi, K. Miyazawa, H. Endo, et al.
A Member of Forkhead Transcription Factor FKHRL1 Is a Downstream Effector of STI571-induced Cell Cycle Arrest in BCR-ABL-expressing Cells
J. Biol. Chem.,
February 14, 2003;
278(8):
6411 - 6419.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Salesse and C. M. Verfaillie
BCR/ABL-mediated Increased Expression of Multiple Known and Novel Genes That May Contribute to the Pathogenesis of Chronic Myelogenous Leukemia
Mol. Cancer Ther.,
February 1, 2003;
2(2):
173 - 182.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mayerhofer, P. Valent, W. R. Sperr, J. D. Griffin, and C. Sillaber
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha , through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
Blood,
November 15, 2002;
100(10):
3767 - 3775.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Holtz, M. L. Slovak, F. Zhang, C. L. Sawyers, S. J. Forman, and R. Bhatia
Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation
Blood,
May 15, 2002;
99(10):
3792 - 3800.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Glei{beta}ner, N. Gokbuget, C. R. Bartram, B. Janssen, H. Rieder, J. W. G. Janssen, C. Fonatsch, A. Heyll, D. Voliotis, J. Beck, et al.
Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis
Blood,
March 1, 2002;
99(5):
1536 - 1543.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Savage and K. H. Antman
Imatinib Mesylate -- A New Oral Targeted Therapy
N. Engl. J. Med.,
February 28, 2002;
346(9):
683 - 693.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. N. Rylova, A. Amalfitano, D.-A. Persaud-Sawin, W.-X. Guo, J. Chang, P. J. Jansen, A. D. Proia, and R.-M. Boustany
The CLN3 Gene is a Novel Molecular Target for Cancer Drug Discovery
Cancer Res.,
February 1, 2002;
62(3):
801 - 808.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M. F. Mow, J. Chandra, P. A. Svingen, C. G. Hallgren, E. Weisberg, T. J. Kottke, V. L. Narayanan, M. R. Litzow, J. D. Griffin, E. A. Sausville, et al.
Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro
Blood,
January 15, 2002;
99(2):
664 - 671.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Mauro, M. O'Dwyer, M. C. Heinrich, and B. J. Druker
STI571: A Paradigm of New Agents for Cancer Therapeutics
J. Clin. Oncol.,
January 1, 2002;
20(1):
325 - 334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Hawk, T. Sun, S. Xie, Y. Wang, Y. Wu, J. Liu, and R. B. Arlinghaus
Inhibition of the Bcr-Abl Oncoprotein by Bcr Requires Phosphoserine 354
Cancer Res.,
January 1, 2002;
62(2):
386 - 390.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Jena, M. Deng, E. Sicinska, P. Sicinski, and G. Q. Daley
Critical Role for Cyclin D2 in BCR/ABL-induced Proliferation of Hematopoietic Cells
Cancer Res.,
January 1, 2002;
62(2):
535 - 541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Graham, H. G. Jorgensen, E. Allan, C. Pearson, M. J. Alcorn, L. Richmond, and T. L. Holyoake
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
Blood,
January 1, 2002;
99(1):
319 - 325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Goetz, H. van der Kuip, R. Maya, M. Oren, and W. E. Aulitzky
Requirement for Mdm2 in the Survival Effects of Bcr-Abl and Interleukin 3 in Hematopoietic Cells
Cancer Res.,
October 1, 2001;
61(20):
7635 - 7641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. van der Kuip, A. W. Goetz, C. Miething, J. Duyster, and W. E. Aulitzky
Adhesion to fibronectin selectively protects Bcr-Abl+ cells from DNA damage-induced apoptosis
Blood,
September 1, 2001;
98(5):
1532 - 1541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Di Cristofano, M. Niki, M. Zhao, F. G. Karnell, B. Clarkson, W. S. Pear, L. Van Aelst, and P. P. Pandolfi
p62dok, a Negative Regulator of Ras and Mitogen-activated Protein Kinase (MAPK) Activity, Opposes Leukemogenesis by p210bcr-abl
J. Exp. Med.,
July 30, 2001;
194(3):
275 - 284.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Zhao, Y. Jiang, and C. M. Verfaillie
A model of human p210bcr/ABL-mediated chronic myelogenous leukemia by transduction of primary normal human CD34+ cells with a BCR/ABL-containing retroviral vector
Blood,
April 15, 2001;
97(8):
2406 - 2412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
