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Interleukin-11: a multifunctional growth factor derived from the
hematopoietic microenvironment
XX Du and DA Williams
Herman B Wells Center for Pediatric Research, James Whitcomb Riley Hospital
for Children, Indianapolis, IN.
IL-11 is a unique growth factor derived from cells making up the HM.
Although cloned based on IL-6-like bioactivity, IL-11 and IL-6 have
distinct biologic profiles (Table 1). IL-11, like many recently cloned
growth factors, has pleiotropic effects on hematopoietic cells presumably
depending on the cytokine and cellular environment into which it is
introduced. However, some general findings are consistent (Table 2). In
addition, IL-11 has significant effects, either primary or secondary, on
nonhematopoietic cells, including neurons, small intestine crypt
progenitor/stem cells, and preadipocytes. The institution of human trials
with IL-11 will provide important information on the pharmacologic effects
of IL-11 on human hematopoietic cells in the context of frequently used
chemotherapy protocols. The physiologic role(s) of IL-11 are unknown but
will become clear (at least in the mouse) with gene targeting experiments
underway in several laboratories.
Volume 83,
Issue 8,
pp. 2023-2030,
04/15/1994
Copyright © 1994 by The American Society of Hematology
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