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Interleukin-13 induces the production of interleukin-1 receptor antagonist
(IL-1ra) and the expression of the mRNA for the intracellular
(keratinocyte) form of IL-1ra in human myelomonocytic cells
M Muzio, F Re, M Sironi, N Polentarutti, A Minty, D Caput, P Ferrara, A Mantovani and F Colotta
Istituto di Ricerche Farmacologiche Mario Negri, Centro Daniela e Catullo
Borgomainerio, Milano, Italy.
The aim of this study was to examine the expression of interleukin-1
receptor antagonist (IL-1ra) in human myelomonocytic cells treated with
IL-13. IL-13 induced IL-1ra transcripts in human circulating monocytes and
polymorphonuclear cells (PMN). Induction by IL-13 was not blocked, but
rather superinduced, in the presence of the protein synthesis inhibitor
cycloheximide. Actinomycin D blocked induction, suggesting involvement of
gene transcription. The half-life of IL-1ra transcripts was prolonged by
IL-13 from 1.3 hours to 4.5 hours in monocytes and to 12 hours in PMN. By
reverse transcriptase-polymerase chain reaction, IL- 13 was found to
augment the transcripts coding for the soluble form of IL-1ra, but also to
induce the expression of the intracellular (keratinocyte) form of IL-1ra,
the latter being extremely low or undetectable in myelomonocytic cells.
IL-13 induced production of IL- 1ra in myelomonocytic cells, augmenting
both cell-associated and released protein. Induction of IL-1ra by IL-13 may
represent a further mechanism by which this molecule can counteract the
potent proinflammatory properties of IL-1.
Volume 83,
Issue 7,
pp. 1738-1743,
04/01/1994
Copyright © 1994 by The American Society of Hematology
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