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Immunoglobulin V regions and the B cell
AK Stewart and RS Schwartz
Division of Hematology-Oncology, Toronto Hospital, Ontario, Canada.
There is now substantial evidence that a small group of V genes
predominates in the Ig repertoire of preimmune B cells. This phenomenon of
V gene restriction may reflect preferential accessibility of these genes to
recombinase, homology-directed V gene rearrangement, promoters and enhances
of V gene transcription, or positive and negative selection mediated by the
anti-self binding properties of the B cells surface Ig. These mechanisms
may operate alone or in combination to influence V gene rearrangement and
populations of immature B cells. Although constraints on the pool of
rearranged V genes may seem disadvantageous to the immune system, the
mechanisms that generate the CDR3s of heavy and light chains ensure
extensive diversity in the pre-B- cell population. In mature B cells,
somatic mutation of V genes adds further diversity. CDR3 sequences and
somatic mutations not only provide potentially useful clonal markers but
also help to identify the normal counterparts of malignant B cells.
Volume 83,
Issue 7,
pp. 1717-1730,
04/01/1994
Copyright © 1994 by The American Society of Hematology
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