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Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human
monocytes
T Musso, GL Gusella, A Brooks, DL Longo and L Varesio
Biological Carcinogenesis and Development Program, PRI/DynCorp, Turin,
Italy.
Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes
the conversion of tryptophan to kynurenine, is induced in peripheral blood
mononuclear cells by interferon-gamma (IFN gamma). Interleukin-4 (IL-4) is
a cytokine that modulates the functional properties of
monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We
showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by
IFN gamma in human monocytes. The inhibitory effect was evident with as
little as 2 U/mL of IL-4. These results provide the first evidence that a
cytokine can provide a negative signal for IDO expression and that IL-4 can
influence the catabolism of tryptophan.
Volume 83,
Issue 5,
pp. 1408-1411,
03/01/1994
Copyright © 1994 by The American Society of Hematology
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