|
|
 Previous Article | Table of Contents | Next Article 
Platelet adhesion to collagen types I through VIII under conditions of
stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin)
EU Saelman, HK Nieuwenhuis, KM Hese, PG de Groot, HF Heijnen, EH Sage, S Williams, L McKeown, HR Gralnick and JJ Sixma
Department of Haematology, University Hospital Utrecht, The Netherlands.
Platelet adhesion to fibrillar collagens (types I, II, III, and V) and
nonfibrillar collagens (types IV, VI, VII, and VIII) was investigated in
the presence of physiologic concentrations of divalent cations under
conditions of stasis and flow. Under static conditions, platelet adhesion
was observed to collagen types I through VII but not to type VIII. Under
flow conditions, platelet adhesion to collagen types I, II, III, and IV was
almost independent of shear rates above 300/s. Collagen type V was
nonadhesive. Platelet adhesion to collagen type VI was shear rate-dependent
and optimal at a rate of 300/s. Collagen types VII and VIII showed minor
reactivity and supported platelet adhesion only between shear rates 100 to
1,000/s. Monoclonal antibody (MoAb) 176D7, directed against platelet
membrane glycoprotein Ia (GPIa; very late antigen [VLA]-alpha 2 subunit),
completely inhibited platelet adhesion to all collagens tested, under
conditions of both stasis and flow. Platelet adhesion to collagen type III
at shear rate 1,600/s was only inhibited for 85%. The concentration of
antibody required for complete inhibition of platelet adhesion was
dependent on the shear rate and the reactivity of the collagen. An MoAb
directed against GPIIa (VLA-beta subunit) partially inhibited platelet
adhesion to collagen. These results show that GPIa-IIa is a major and
universal platelet receptor for eight unique types of collagen.
Volume 83,
Issue 5,
pp. 1244-1250,
03/01/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
U. M. Okorie and S. L. Diamond
Matrix Protein Microarrays for Spatially and Compositionally Controlled Microspot Thrombosis under Laminar Flow
Biophys. J.,
November 1, 2006;
91(9):
3474 - 3481.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Yacoub, J.-F. Theoret, L. Villeneuve, H. Abou-Saleh, W. Mourad, B. G. Allen, and Y. Merhi
Essential Role of Protein Kinase C{delta} in Platelet Signaling, {alpha}IIbbeta3 Activation, and Thromboxane A2 Release
J. Biol. Chem.,
October 6, 2006;
281(40):
30024 - 30035.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Turner, M. O. Murphy, C. M. Kielty, C. A. Shuttleworth, R. A. Black, M. J. Humphries, M. G. Walker, and A. E. Canfield
{alpha}2(VIII) Collagen Substrata Enhance Endothelial Cell Retention Under Acute Shear Stress Flow via an {alpha}2{beta}1 Integrin-Dependent Mechanism: An In Vitro and In Vivo Study
Circulation,
August 22, 2006;
114(8):
820 - 829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Antoniades, D. Tousoulis, C. Vasiliadou, E. Stefanadi, K. Marinou, and C. Stefanadis
Genetic Polymorphisms of Platelet Glycoprotein Ia and the Risk for Premature Myocardial Infarction: Effects on the Release of sCD40L During the Acute Phase of Premature Myocardial Infarction
J. Am. Coll. Cardiol.,
May 16, 2006;
47(10):
1959 - 1966.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Raynal, S. W. Hamaia, P. R.-M. Siljander, B. Maddox, A. R. Peachey, R. Fernandez, L. J. Foley, D. A. Slatter, G. E. Jarvis, and R. W. Farndale
Use of Synthetic Peptides to Locate Novel Integrin {alpha}2beta1-binding Motifs in Human Collagen III
J. Biol. Chem.,
February 17, 2006;
281(7):
3821 - 3831.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ogino, J. Kido, M. Bando, N. Hayashi, C. Wada, T. Nagata, F. Nishimura, Y. Soga, S. Takashiba, T. Kubota, et al.
{alpha}2 Integrin +807 Polymorphism in Drug-induced Gingival Overgrowth
Journal of Dental Research,
December 1, 2005;
84(12):
1183 - 1186.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. Sarratt, H. Chen, M. M. Zutter, S. A. Santoro, D. A. Hammer, and M. L. Kahn
GPVI and {alpha}2{beta}1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow
Blood,
August 15, 2005;
106(4):
1268 - 1277.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mazharian, S. Roger, P. Maurice, E. Berrou, M. R. Popoff, M. F. Hoylaerts, F. Fauvel-Lafeve, A. Bonnefoy, and M. Bryckaert
Differential Involvement of ERK2 and p38 in Platelet Adhesion to Collagen
J. Biol. Chem.,
July 15, 2005;
280(28):
26002 - 26010.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Cruz, J. Chen, J. L. Whitelock, L. D. Morales, and J. A. Lopez
The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor {alpha}2{beta}1 to bind collagen: activation-dependent conformational change of the {alpha}2-I domain
Blood,
March 1, 2005;
105(5):
1986 - 1991.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R.-M. Siljander, S. Hamaia, A. R. Peachey, D. A. Slatter, P. A. Smethurst, W. H. Ouwehand, C. G. Knight, and R. W. Farndale
Integrin Activation State Determines Selectivity for Novel Recognition Sites in Fibrillar Collagens
J. Biol. Chem.,
November 12, 2004;
279(46):
47763 - 47772.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Calzada, D. S. Annis, B. Zeng, C. Marcinkiewicz, B. Banas, J. Lawler, D. F. Mosher, and D. D. Roberts
Identification of Novel {beta}1 Integrin Binding Sites in the Type 1 and Type 2 Repeats of Thrombospondin-1
J. Biol. Chem.,
October 1, 2004;
279(40):
41734 - 41743.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-P. Wu, H. J. Bloemendal, E. E. Voest, T. Logtenberg, P. G. de Groot, M. F. B. G. Gebbink, and H. C. de Boer
Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin
Blood,
August 15, 2004;
104(4):
1034 - 1041.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Gibbins
Platelet adhesion signalling and the regulation of thrombus formation
J. Cell Sci.,
July 15, 2004;
117(16):
3415 - 3425.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R.-M. Siljander, I. C. A. Munnix, P. A. Smethurst, H. Deckmyn, T. Lindhout, W. H. Ouwehand, R. W. Farndale, and J. W. M. Heemskerk
Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood
Blood,
February 15, 2004;
103(4):
1333 - 1341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Polanowska-Grabowska, J. M. Gibbins, and A. R.L. Gear
Platelet Adhesion to Collagen and Collagen-Related Peptide Under Flow: Roles of the {alpha}2{beta}1 Integrin, GPVI, and Src Tyrosine Kinases
Arterioscler. Thromb. Vasc. Biol.,
October 1, 2003;
23(10):
1934 - 1940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Nieswandt and S. P. Watson
Platelet-collagen interaction: is GPVI the central receptor?
Blood,
July 15, 2003;
102(2):
449 - 461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Joutsi-Korhonen, P. A. Smethurst, A. Rankin, E. Gray, M. IJsseldijk, C. M. Onley, N. A. Watkins, L. M. Williamson, A. H. Goodall, P. G. de Groot, et al.
The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression
Blood,
June 1, 2003;
101(11):
4372 - 4379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Goel and Scott. L. Diamond
Neutrophil Cathepsin G Promotes Prothrombinase and Fibrin Formation under Flow Conditions by Activating Fibrinogen-adherent Platelets
J. Biol. Chem.,
March 7, 2003;
278(11):
9458 - 9463.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Spessotto, M. Cervi, M. T. Mucignat, G. Mungiguerra, I. Sartoretto, R. Doliana, and A. Colombatti
beta 1 Integrin-dependent Cell Adhesion to EMILIN-1 Is Mediated by the gC1q Domain
J. Biol. Chem.,
February 14, 2003;
278(8):
6160 - 6167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Patel, H. Vaananen, M. Jirouskova, T. Hoffmann, C. Bodian, and B. S. Coller
Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy
Blood,
February 1, 2003;
101(3):
929 - 936.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Matsui, M. Sugimoto, T. Mizuno, S. Tsuji, S. Miyata, M. Matsuda, and A. Yoshioka
Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow
Blood,
November 15, 2002;
100(10):
3604 - 3610.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Goel and S. L. Diamond
Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma
Blood,
November 15, 2002;
100(10):
3797 - 3803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Holtkotter, B. Nieswandt, N. Smyth, W. Muller, M. Hafner, V. Schulte, T. Krieg, and B. Eckes
Integrin alpha 2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen
J. Biol. Chem.,
March 22, 2002;
277(13):
10789 - 10794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Nykvist, K. Tasanen, T. Viitasalo, J. Kapyla, J. Jokinen, L. Bruckner-Tuderman, and J. Heino
The Cell Adhesion Domain of Type XVII Collagen Promotes Integrin-mediated Cell Spreading by a Novel Mechanism
J. Biol. Chem.,
October 12, 2001;
276(42):
38673 - 38679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Bouvard, C. Brakebusch, E. Gustafsson, A. Aszodi, T. Bengtsson, A. Berna, and R. Fassler
Functional Consequences of Integrin Gene Mutations in Mice
Circ. Res.,
July 30, 2001;
89(3):
211 - 223.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Kauhanen, P. T. Kovanen, and R. Lassila
Coimmobilized Native Macromolecular Heparin Proteoglycans Strongly Inhibit Platelet-Collagen Interactions in Flowing Blood
Arterioscler. Thromb. Vasc. Biol.,
November 1, 2000;
20
(11):
e113 - e119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Roest, J. D. Banga, D. E. Grobbee, P. G. de Groot, J. J. Sixma, M. J. Tempelman, and Y. T. van der Schouw
Homozygosity for 807 T Polymorphism in {alpha}2 Subunit of Platelet {alpha}2{beta}1 Is Associated With Increased Risk of Cardiovascular Mortality in High-Risk Women
Circulation,
October 3, 2000;
102(14):
1645 - 1650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Roest, J. J. Sixma, Y.-P. Wu, M. J. W. Ijsseldijk, M. Tempelman, P. J. Slootweg, P. G. de Groot, and G. H. van Zanten
Platelet adhesion to collagen in healthy volunteers is influenced by variation of both alpha 2beta 1 density and von Willebrand factor
Blood,
August 15, 2000;
96(4):
1433 - 1437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-P. Wu, T. Vink, M. Schiphorst, G. H. van Zanten, M. J. W. IJsseldijk, P. G. de Groot, and J. J. Sixma
Platelet Thrombus Formation on Collagen at High Shear Rates Is Mediated by von Willebrand Factor-Glycoprotein Ib Interaction and Inhibited by von Willebrand Factor-Glycoprotein IIb/IIIa Interaction
Arterioscler. Thromb. Vasc. Biol.,
June 1, 2000;
20(6):
1661 - 1667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Nykvist, H. Tu, J. Ivaska, J. Kapyla, T. Pihlajaniemi, and J. Heino
Distinct Recognition of Collagen Subtypes by alpha 1beta 1 and alpha 2beta 1 Integrins. alpha 1beta 1 MEDIATES CELL ADHESION TO TYPE XIII COLLAGEN
J. Biol. Chem.,
March 10, 2000;
275(11):
8255 - 8261.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Smith, D. Estavillo, J. Emsley, L. A. Bankston, R. C. Liddington, and M. A. Cruz
Mapping the Collagen-binding Site in the I Domain of the Glycoprotein Ia/IIa (Integrin alpha 2beta 1)
J. Biol. Chem.,
February 11, 2000;
275(6):
4205 - 4209.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Santoso, J. Amrhein, H. A. Hofmann, U. J.H. Sachs, M. M. Walka, H. Kroll, and V. Kiefel
A Point Mutation Thr799Met on the alpha 2 Integrin Leads to the Formation of New Human Platelet Alloantigen Sita and Affects Collagen-Induced Aggregation
Blood,
December 15, 1999;
94(12):
4103 - 4111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Estavillo, A. Ritchie, T. G. Diacovo, and M. A. Cruz
Functional Analysis of a Recombinant Glycoprotein Ia/IIa (Integrin alpha 2beta 1) I Domain That Inhibits Platelet Adhesion to Collagen and Endothelial Matrix under Flow Conditions
J. Biol. Chem.,
December 10, 1999;
274(50):
35921 - 35926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Siljander and R. Lassila
Studies of Adhesion-Dependent Platelet Activation : Distinct Roles for Different Participating Receptors Can Be Dissociated by Proteolysis of Collagen
Arterioscler. Thromb. Vasc. Biol.,
December 1, 1999;
19(12):
3033 - 3043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Savage, M. H. Ginsberg, and Z. M. Ruggeri
Influence of Fibrillar Collagen Structure on the Mechanisms of Platelet Thrombus Formation Under Flow
Blood,
October 15, 1999;
94(8):
2704 - 2715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tsuji, M. Sugimoto, S. Miyata, M. Kuwahara, S. Kinoshita, and A. Yoshioka
Real-Time Analysis of Mural Thrombus Formation in Various Platelet Aggregation Disorders: Distinct Shear-Dependent Roles of Platelet Receptors and Adhesive Proteins Under Flow
Blood,
August 1, 1999;
94(3):
968 - 975.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Di Paola, A. B. Federici, P.M. Mannucci, M. T. Canciani, M. Kritzik, T. J. Kunicki, and D. Nugent
Low Platelet alpha 2beta 1 Levels in Type I von Willebrand Disease Correlate With Impaired Platelet Function in a High Shear Stress System
Blood,
June 1, 1999;
93(11):
3578 - 3582.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Briddon, S. K. Melford, M. Turner, V. Tybulewicz, and S. P. Watson
Collagen Mediates Changes in Intracellular Calcium in Primary Mouse Megakaryocytes Through syk-Dependent and -Independent Pathways
Blood,
June 1, 1999;
93(11):
3847 - 3855.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Zutter, A. D. Painter, and X. Yang
The Megakaryocyte/Platelet-Specific Enhancer of the alpha 2beta 1 Integrin Gene: Two Tandem AP1 Sites and the Mitogen-Activated Protein Kinase Signaling Cascade
Blood,
March 1, 1999;
93(5):
1600 - 1611.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mazzucato, P. Spessotto, A. Masotti, L. De Appollonia, M. R. Cozzi, A. Yoshioka, R. Perris, A. Colombatti, and L. De Marco
Identification of Domains Responsible for von Willebrand Factor Type VI Collagen Interaction Mediating Platelet Adhesion under High Flow
J. Biol. Chem.,
January 29, 1999;
274(5):
3033 - 3041.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Jung and M. Moroi
Platelets Interact with Soluble and Insoluble Collagens through Characteristically Different Reactions
J. Biol. Chem.,
June 12, 1998;
273(24):
14827 - 14837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
