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Production of hematopoietic stem cell-chemotactic factor by bone marrow
stromal cells
Cherry, R Yasumizu, J Toki, H Asou, T Nishino, Y Komatsu and S Ikehara
Department of Pathology, Kansai Medical University, Osaka, Japan.
Chemotactic factors produced by stromal cells in the bone marrow are
characterized. Two kinds of factors produced by stromal cell lines are
identified using blind-well Boyden's Chambers; one is a neutrophil-
chemotactic factor and the other a hematopoietic stem cell (HSC)-
chemotactic factor. The latter attracts blastic cells in a low-density
fraction, which are Thy1lo, wheat germ agglutinin (WGA)hi, H-2Khi, Ly-1- ,
Ly-2-, L3T4-, Ly5-, and slg-. The molecular weight of this HSC- chemotactic
factor is estimated to be more than 200 kD. Putative cytokines and growth
factors, such as granulocyte colony-stimulating factor (CSF), macrophage
CSF, granulocyte-macrophage CSF, stem cell factor (SCF), interleukin
(IL)-6, and IL-3, do not possess HSC- chemotactic activity. These findings
strongly suggest that bone marrow stromal cells produce a new factor that
attracts HSCs.
Volume 83,
Issue 4,
pp. 964-971,
02/15/1994
Copyright © 1994 by The American Society of Hematology
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