|
|
 Previous Article | Table of Contents | Next Article 
Proliferative but not nonproliferative responses to granulocyte colony-
stimulating factor are associated with rapid activation of the p21ras/MAP
kinase signalling pathway
A Bashey, L Healy and CJ Marshall
Section of Cell and Molecular Biology, Chester Beatty Laboratories,
Institute of Cancer Research, London, UK.
Granulocyte colony-stimulating factor (G-CSF) can elicit responses that
include proliferation, granulocytic differentiation, and activation of
cellular functions in target cells. The biochemical pathways responsible
for transduction of these signals from the G-CSF receptor (G-CSFR) have not
been defined. In this report, we show that, in murine (NFS-60) and human
(OCI-AML 1) myeloid leukemia cell lines and in murine pro-B-lymphocytic
cells, BAF/B03, transfected with the murine G- CSFR, proliferative
responses to G-CSF are associated with rapid activation of p42 and p44 MAP
kinases and p21ras. Truncation of the cytoplasmic portion of the murine
G-CSFR at residue 646 but not at residue 739 abolished G-CSF-induced
stimulation of cellular proliferation as well as activation of MAP kinase
and p21ras in transfected BAF/B03 cells. G-CSF-induced granulocytic
differentiation of the murine leukemic cell line 32DC13(G) occurred in the
absence of detectable activation of p42 MAP kinase. Nonproliferative
responses to G-CSF in the human promyelocytic cell line HL-60 and in human
neutrophils were similarly associated with no MAP kinase activation. These
results imply that differing cellular effects of G-CSF may be involve the
recruitment of differing signal transduction pathways with the p21ras/MAP
kinase pathway being limited to proliferative responses.
Volume 83,
Issue 4,
pp. 949-957,
02/15/1994
Copyright © 1994 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Iida, R. Watanabe-Fukunaga, S. Nagata, and R. Fukunaga
Essential role of C/EBPalpha in G-CSF-induced transcriptional activation and chromatin modification of myeloid-specific genes.
Genes Cells,
April 1, 2008;
13(4):
313 - 327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Germeshausen, M. Ballmaier, and K. Welte
Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey
Blood,
January 1, 2007;
109(1):
93 - 99.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q.-S. Zhu, L. J. Robinson, V. Roginskaya, and S. J. Corey
G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses
Blood,
May 1, 2004;
103(9):
3305 - 3312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kusano, S. Ebara, K. Tachibana, T. Nishimura, S. Sato, T. Kuwaki, and T. Taniyama
A potential therapeutic role for small nonpeptidyl compounds that mimic human granulocyte colony-stimulating factor
Blood,
February 1, 2004;
103(3):
836 - 842.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. J. Aarts, O. Roovers, A. C. Ward, and I. P. Touw
Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics
Blood,
January 15, 2004;
103(2):
571 - 579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Kendrick, R. J. Lipscombe, O. Rausch, S. E. Nicholson, J. E. Layton, L. C. Goldie-Cregan, and M. A. Bogoyevitch
Contribution of the Membrane-distal Tyrosine in Intracellular Signaling by the Granulocyte Colony-stimulating Factor Receptor
J. Biol. Chem.,
January 2, 2004;
279(1):
326 - 340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. A. Hermans, G.-J. van de Geijn, C. Antonissen, J. Gits, D. van Leeuwen, A. C. Ward, and I. P. Touw
Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells
Blood,
April 1, 2003;
101(7):
2584 - 2590.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Apati, J. Janossy, A. Brozik, P. I. Bauer, and M. Magocsi
Calcium Induces Cell Survival and Proliferation through the Activation of the MAPK Pathway in a Human Hormone-dependent Leukemia Cell Line, TF-1
J. Biol. Chem.,
March 7, 2003;
278(11):
9235 - 9243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Jorda, B. Lowenberg, and R. Delwel
The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation
Blood,
February 15, 2003;
101(4):
1336 - 1343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hortner, U. Nielsch, L. M. Mayr, J. A. Johnston, P. C. Heinrich, and S. Haan
Suppressor of Cytokine Signaling-3 Is Recruited to the Activated Granulocyte-Colony Stimulating Factor Receptor and Modulates its Signal Transduction
J. Immunol.,
August 1, 2002;
169(3):
1219 - 1227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Akbarzadeh, A. C. Ward, D. O. M. McPhee, W. S. Alexander, G. J. Lieschke, and J. E. Layton
Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells
Blood,
February 1, 2002;
99(3):
879 - 887.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dong, Y. Qiu, T. Yi, I. P. Touw, and A. C. Larner
The Carboxyl Terminus of the Granulocyte Colony- Stimulating Factor Receptor, Truncated in Patients with Severe Congenital Neutropenia/Acute Myeloid Leukemia, Is Required for SH2-Containing Phosphatase-1 Suppression of Stat Activation
J. Immunol.,
December 1, 2001;
167(11):
6447 - 6452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. C. von Lintig, I. Huvar, P. Law, M. B. Diccianni, A. L. Yu, and G. R. Boss
Ras Activation in Normal White Blood Cells and Childhood Acute Lymphoblastic Leukemia
Clin. Cancer Res.,
May 1, 2000;
6(5):
1804 - 1810.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Dong and A. C. Larner
Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): evidence for the role of a tyrosine kinase activity distinct from the janus kinases
Blood,
March 1, 2000;
95(5):
1656 - 1662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yamaguchi, T. Mukasa, E. Uchida, T. Kanayasu-Toyoda, and T. Hayakawa
The Role of STAT3 in Granulocyte Colony-stimulating Factor-induced Enhancement of Neutrophilic Differentiation of Me2SO-treated HL-60 Cells. GM-CSF INHIBITS THE NUCLEAR TRANSLOCATION OF TYROSINE-PHOSPHORYLATED STAT3
J. Biol. Chem.,
May 28, 1999;
274(22):
15575 - 15581.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Ward, L. Smith, J. P. de Koning, Y. van Aesch, and I. P. Touw
Multiple Signals Mediate Proliferation, Differentiation, and Survival from the Granulocyte Colony-stimulating Factor Receptor in Myeloid 32D Cells
J. Biol. Chem.,
May 21, 1999;
274(21):
14956 - 14962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Ward, Y. M. van Aesch, A. M. Schelen, and I. P. Touw
Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia
Blood,
January 15, 1999;
93(2):
447 - 458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Suzuki, M. Hino, F. Hato, N. Tatsumi, and S. Kitagawa
Cytokine-Specific Activation of Distinct Mitogen-Activated Protein Kinase Subtype Cascades in Human Neutrophils Stimulated by Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, and Tumor Necrosis Factor-alpha
Blood,
January 1, 1999;
93(1):
341 - 349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dong, X. Liu, J. P. de Koning, I. P. Touw, L. Henninghausen, A. Larner, and P. M. Grimley
Stimulation of Stat5 by Granulocyte Colony-Stimulating Factor (G-CSF) Is Modulated by Two Distinct Cytoplasmic Regions of the G-CSF Receptor
J. Immunol.,
December 15, 1998;
161(12):
6503 - 6509.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Inoue, H. Tamaki, H. Ogawa, Y. Oka, T. Soma, T. Tatekawa, Y. Oji, A. Tsuboi, E. H. Kim, M. Kawakami, et al.
Wilms' Tumor Gene (WT1) Competes With Differentiation-Inducing Signal in Hematopoietic Progenitor Cells
Blood,
April 15, 1998;
91(8):
2969 - 2976.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Melemed, J. W. Ryder, and T. A. Vik
Activation of the Mitogen-Activated Protein Kinase Pathway Is Involved in and Sufficient for Megakaryocytic Differentiation of CMK Cells
Blood,
November 1, 1997;
90(9):
3462 - 3470.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Valk, S. Verbakel, Y. Vankan, S. Hol, S. Mancham, R. Ploemacher, A. Mayen, B. Lowenberg, and R. Delwel
Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells
Blood,
August 15, 1997;
90(4):
1448 - 1457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Fine, X.-Y. Cai, L. Justice, C. P. Gommoll Jr, L. D. Hamilton, T. A. Waters, S. K. Narula, L. A. Bober, and M. J. Grace
A Specific Stimulator of Granulocyte Colony-Stimulating Factor Accelerates Recovery From Cyclophosphamide-Induced Neutropenia in the Mouse
Blood,
July 15, 1997;
90(2):
795 - 802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Aronica, A.-C. Gingras, N. Sonenberg, S. Cooper, N. Hague, and H. E. Broxmeyer
Macrophage Inflammatory Protein-1alpha and Interferon-Inducible Protein 10 Inhibit Synergistically Induced Growth Factor Stimulation of MAP Kinase Activity and Suppress Phosphorylation of Eukaryotic Initiation Factor 4E and 4E Binding Protein 1
Blood,
May 15, 1997;
89(10):
3582 - 3595.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Terada, Y. Kaziro, and T. Satoh
Ras-dependent Activation of c-Jun N-terminal Kinase/Stress-activated Protein Kinase in Response to Interleukin-3 Stimulation in Hematopoietic BaF3 Cells
J. Biol. Chem.,
February 14, 1997;
272(7):
4544 - 4548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Desrivieres, S. Desrivières, and S. Ferrari
Evidence for Different Mechanisms of Growth Inhibition of T-cell Lymphoma by Phorbol Esters and Concanavalin A
J. Biol. Chem.,
January 24, 1997;
272(4):
2470 - 2476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
GregoryP. Downey, JeffreyR. Butler, J. Brumell, N. Borregaard, L. Kjeldsen, AndreaK. Sue-A-Quan, and S. Grinstein
Chemotactic Peptide-induced Activation of MEK-2, the Predominant Isoform in Human Neutrophils. INHIBITION BY WORTMANNIN
J. Biol. Chem.,
August 30, 1996;
271(35):
21005 - 21011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Tilbrook, T. Bittorf, S. J. Busfield, D. Chappell, and S. P. Klinken
Disrupted Signaling in a Mutant J2E Cell Line That Shows Enhanced Viability, but Does Not Proliferate or Differentiate, with Erythropoietin
J. Biol. Chem.,
February 16, 1996;
271(7):
3453 - 3459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Owen-Lynch, A. K. Y. Wong, and A. D. Whetton
v-Abl-mediated Apoptotic Suppression Is Associated with SHC Phosphorylation without Concomitant Mitogen-activated Protein Kinase Activation
J. Biol. Chem.,
March 17, 1995;
270(11):
5956 - 5962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dong, J. S. Gutkind, and A. C. Larner
Granulocyte Colony-stimulating Factor Induces Erk5 Activation, Which Is Differentially Regulated by Protein-tyrosine Kinases and Protein Kinase C. REGULATION OF CELL PROLIFERATION AND SURVIVAL
J. Biol. Chem.,
March 30, 2001;
276(14):
10811 - 10816.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
