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p53 mutations are associated with histologic transformation of follicular
lymphoma
F Lo Coco, G Gaidano, DC Louie, K Offit, RS Chaganti and R Dalla-Favera
Department of Pathology, College of Physicians and Surgeons, Columbia
University, New York, NY 10032.
The majority of low-grade non-Hodgkin's lymphomas (NHL) undergo clinical
progression toward intermediate- and high-grade lymphomas. This progression
is often associated with histologic transformation from follicular to
diffuse-type NHL. The pathogenetic mechanisms underlying this evolution are
presently unknown. In this study, we have analyzed the role in NHL
progression of relevant genetic lesions affecting proto-oncogenes and tumor
suppressor genes. Sequential biopsies from 21 patients with clinical
progression with (5 cases) or without (16 cases) evidence of histologic
transformation were analyzed for karyotypic changes, c-myc rearrangements
and deletions affecting 6q27 by Southern blot analysis, and p53 mutations
by single-strand conformation polymorphism (SSCP) analysis coupled with
direct sequencing of polymerase chain reaction-amplified products. No novel
cytogenetic aberration was detected in association with progression, and
all samples analyzed displayed a normal c-myc gene. Mutations of the p53
gene were detected in 4 of 5 cases displaying histologic transformation
from follicular to diffuse-type NHL and in none of the 16 cases displaying
clinical progression in the absence of histologic transformation. In 1 of
these positive cases, the same mutation was also present in the
pretransformation biopsy, correlating with the presence of diffuse-type
areas within a predominant follicular pattern. In 1 of these cases, a
deletion of 6q27 was also detected in the posttransformation biopsy along
with a p53 mutation. These findings indicate that p53 mutations are
associated with and may be responsible for histologic transformation of
follicular lymphoma.
Volume 82,
Issue 8,
pp. 2289-2295,
10/15/1993
Copyright © 1993 by The American Society of Hematology
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|
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12(19):
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|
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|
|
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|
|
|
|
|
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58(6):
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|
|
|
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|
|
|
|
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|
|
|
|
|
|
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102(4):
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|
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|
|
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|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
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|
|
|
|
|
|
|
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1315 - 1322.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M.A. Thornton, M. Poncz, M. Korostishevsky, E. Yakobson, S. Usher, U. Seligsohn, and H. Peretz
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94(6):
2039 - 2047.
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[Full Text]
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|
|
|
|
|
|
|
A. M. Morrison, U. Jager, A. Chott, M. Schebesta, O. A. Haas, and M. Busslinger
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Blood,
November 15, 1998;
92(10):
3865 - 3878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.H.H. Kramer, J. Hermans, E. Wijburg, K. Philippo, E. Geelen, J.H.J.M. van Krieken, D. de Jong, E. Maartense, E. Schuuring, and P.M. Kluin
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92(9):
3152 - 3162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Cordone, S. Masi, F. R. Mauro, S. Soddu, O. Morsilli, T. Valentini, M. L. Vegna, C. Guglielmi, F. Mancini, S. Giuliacci, et al.
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June 1, 1998;
91(11):
4342 - 4349.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pinyol, F. Cobo, S. Bea, P. Jares, I. Nayach, P. L. Fernandez, E. Montserrat, A. Cardesa, and E. Campo
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April 15, 1998;
91(8):
2977 - 2984.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R.K. Koduru, K. Raju, V. Vadmal, G. Menezes, S. Shah, M. Susin, J. Kolitz, and J. D. Broome
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Blood,
November 15, 1997;
90(10):
4078 - 4091.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Jennings and K. A. Foon
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October 15, 1997;
90(8):
2863 - 2892.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Lens, P. J.J.C. De Schouwer, R. A. Hamoudi, M. Abdul-Rauf, N. Farahat, E. Matutes, T. Crook, M. J.S. Dyer, and D. Catovsky
p53 Abnormalities in B-Cell Prolymphocytic Leukemia
Blood,
March 15, 1997;
89(6):
2015 - 2023.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Matolcsy, P. Casali, R. G. Nador, Y.-F. Liu, and D. M. Knowles
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Blood,
March 1, 1997;
89(5):
1732 - 1739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Ott, J. Kalla, M. M. Ott, B. Schryen, T. Katzenberger, J. G. Muller, and H. K. Muller-Hermelink
Blastoid Variants of Mantle Cell Lymphoma: Frequent bcl-1 Rearrangements at the Major Translocation Cluster Region and Tetraploid Chromosome Clones
Blood,
February 15, 1997;
89(4):
1421 - 1429.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Gamberi, G. Gaidano, N. Parsa, A. Carbone, S. Roncella, D. M. Knowles, D. C. Louie, D. Shibata, R.S.K. Chaganti, and R. Dalla-Favera
Microsatellite Instability Is Rare in B-Cell Non-Hodgkin's Lymphomas
Blood,
February 1, 1997;
89(3):
975 - 979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Dalla-Favera, B.H. Ye, F. Lo Coco, C.-C. Chang, K. Cechova, J. Zhang, A. Migliazza, W. Mellado, H. Niu, S. Chaganti, et al.
BCL-6 and the Molecular Pathogenesis of B-Cell Lymphoma
Cold Spring Harb Symp Quant Biol,
January 1, 1994;
59(0):
117 - 123.
[Abstract]
[PDF]
|
|
|
|
|
