Serum intercellular adhesion molecule-1 in childhood malignancy
CH Pui, X Luo, W Evans, S Martin, A Rugg, J Wilimas, WM Crist and M Hudson
Department of Hematology-Oncology, St Jude Children's Research Hospital,
Memphis, TN 38101.
Levels of soluble intercellular adhesion molecule-1 (ICAM-1) were measured
in serum samples taken at diagnosis from pediatric patients with Hodgkin's
disease (n = 69), acute lymphoblastic leukemia (n = 28), Wilms' tumor (n =
20), osteosarcoma (n = 17), rhabdomyosarcoma (n = 18), or Ewing's sarcoma
(n = 15). Median levels of serum ICAM-1 were significantly higher in acute
lymphoblastic leukemia and Hodgkin's disease than in controls and other
malignancies. Levels were positively correlated with disease stage for
patients with Hodgkin's disease, Ewing's sarcoma or Wilms' tumor, and with
the frequency of relapse in Hodgkin's disease (P = .016). Serum levels were
normal in all of 76 patients tested in remission. It remains to be
determined whether increased serum ICAM-1 levels simply reflect a greater
tumor burden or whether this molecule contributes directly to the
progression of childhood malignancies.
Volume 82,
Issue 3,
pp. 895-898,
08/01/1993
Copyright © 1993 by The American Society of Hematology
