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Growth and spread of human malignant T lymphoblasts in immunosuppressed
nude mice: a model for meningeal leukemia
F Cavallo, M Forni, C Riccardi, A Soleti, F Di Pierro and G Forni
Institute of Microbiology, University of Turin, Italy.
Previous work has shown that nude (nu/nu) mice additionally
immunosuppressed by splenectomy, sublethal irradiation, and treatment with
antiasialo GM1 antiserum (SIA-nu/nu mice) have no detectable natural killer
activity and allow the growth of human malignant lymphoblasts. We show here
that all SIA-nu/nu mice engrafted intravenously with 5 x 10(6) malignant
lymphoblasts originally derived from a child with a T-cell acute
lymphoblastic leukemia (PF382) and from a boy with a T-cell lymphoma (ST-4)
develop lethal meningeal leukemia and die within 35 days. Histologic
examination of moribund SIA- nu/nu mice showed that vertebral and skull
bone marrow was always replaced by proliferating human T lymphoblasts. From
the spinal canal, lymphoblasts spread to the meninges, causing hind leg
paralysis. Leaving the skull, they permeated the meninges and then invaded
the nervous parenchyma. This efficient and reproducible experimental model
may be suitable for experimental studies on the pathogenesis of meningeal
leukemia.
Volume 80,
Issue 5,
pp. 1279-1283,
09/01/1992
Copyright © 1992 by The American Society of Hematology
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