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Effect of adrenergic agents on hematopoiesis after syngeneic bone marrow transplantation in mice

GJ Maestroni, A Conti and E Pedrinis

Lab for Experimental Pathology, Istituto Cantonale di Patologia, Locarno, Switzerland.

We show that adrenergic agents modulate hematopoietic reconstitution after syngeneic bone marrow transplantation (BMT) in mice. Chemical sympathectomy by 6-hydroxydopamine (6-OHDA) significantly increased the number of peripheral blood leukocytes after syngeneic BMT. The alpha 1- adrenergic antagonist prazosin mimicked and extended the effect of 6- OHDA, with an additional rapid and significant increase of platelets, marrow granulocyte-macrophage colony-forming units, and nucleated spleen cells. Differential leukocyte counts and spleen histology from prazosin-treated mice confirmed that myelopoiesis was greatly enhanced and accelerated. In contrast, the beta-adrenergic blocker propranolol abolished the prazosin-induced increase of platelets. The detailed mechanisms by which prazosin exerts these interesting effects remain to be elucidated.

Volume 80, Issue 5, pp. 1178-1182, 09/01/1992
Copyright © 1992 by The American Society of Hematology


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