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Frequent clonal proliferation of human T-cell leukemia virus type 1
(HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP)
Y Furukawa, J Fujisawa, M Osame, M Toita, S Sonoda, R Kubota, S Ijichi and M Yoshida
Department of Cellular and Molecular Biology, University of Tokyo, Japan.
Human T-cell leukemia virus type 1 (HTLV-1) integrates its proviruses into
random sites in host chromosomal DNA. Random integration of the proviruses
was observed in asymptomatic HTLV-1 carriers and patients with
HTLV-1-associated myelopathy (HAM/TSP). However, clonal integration has
been reported in patients with adult T-cell leukemia (ATL), including that
in the smoldering, chronic, and acute states, indicating clonal expansion
of infected cells. In this study, we found that about 20% of HAM/TSP
patients and their seropositive family members harbored subpopulation(s) of
clonally proliferated cells infected with HTLV-1, although they still
maintained randomly infected cells as a major population. These clones were
stable during examination periods of 4 months to 3 years. However, these
carriers or HAM/TSP patients did not show any significant indication of
ATL. This extremely high frequency of clonal expansion of HTLV-1-infected
cells indicates that some clones of HTLV-1-infected cells have a tendency
to proliferate more efficiently than the other population without malignant
transformation.
Volume 80,
Issue 4,
pp. 1012-1016,
08/15/1992
Copyright © 1992 by The American Society of Hematology
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