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Interleukin-6 production in high-grade B lymphomas: correlation with the
presence of malignant immunoblasts in acquired immunodeficiency syndrome
and in human immunodeficiency virus-seronegative patients
D Emilie, J Coumbaras, M Raphael, O Devergne, HJ Delecluse, C Gisselbrecht, JF Michiels, J Van Damme, T Taga and T Kishimoto
INSERM U131, Clamart, France.
The mechanisms leading to malignant cell proliferation may differ between
the different histologic forms of high-grade non-Hodgkin's lymphomas. To
analyze the potential role of interleukin-6 (IL-6) as a growth factor for
lymphomatous cells in these different forms, the in situ production of this
cytokine was analyzed in lymphomatous samples taken from 24 patients, 18 of
whom were human immunodeficiency virus (HIV) infected. Eleven Burkitt's
lymphomas (BLs), seven diffuse large- cell lymphomas, and six immunoblastic
lymphomas were studied. In situ hybridization experiments showed that the
IL-6 gene was expressed in all tissues. The number of IL-6 gene-expressing
cells was 7 times higher in the non-BLs than in the BLs, and it was 17
times higher than that of 14 control lymph nodes displaying a benign
follicular hyperplasia. Analysis of individual cases indicated that the
level of IL-6 gene expression was strongly correlated with the presence of
immunoblasts within the malignant clone. In contrast, this level was not
correlated with the presence of Epstein-Barr virus genome in the lymphoma
or with the HIV status of patients. Immunohistochemical studies with an
anti-IL-6 monoclonal antibody showed that IL-6 was produced in non-BLs, but
not in BLs. In the former, IL-6 mainly originated from reactive,
nonmalignant cells. Immunohistochemical analyses of non-BLs also showed
that malignant cells produced the 80-Kd chain of the IL-6 receptor. Taken
together, these results suggest that IL-6 may act as a growth factor in
some forms of high-grade B lymphomas. The presence of immunoblasts may be
an indicator of such forms.
Volume 80,
Issue 2,
pp. 498-504,
07/15/1992
Copyright © 1992 by The American Society of Hematology
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