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Distribution and phenotype of Epstein-Barr virus-harboring cells in
Hodgkin's disease
H Herbst, E Steinbrecher, G Niedobitek, LS Young, L Brooks, N Muller-Lantzsch and H Stein
Institute of Pathology, Klinikum Steglitz, Free University of Berlin,
Germany.
Distribution and phenotype of Epstein-Barr virus (EBV)-harboring cells were
determined in Hodgkin's disease (HD) biopsies by in situ hybridization with
[35S]-labeled RNA probes specific for the small EBV- encoded nuclear RNAs,
EBER1 and EBER2, in some instances preceded by immunohistology for CD20,
CD30, CD45RO, and CD68 antigens, the T-cell receptor beta-chain, and latent
membrane antigen (LMP) of EBV. Twenty- three of 46 HD cases displayed EBER
transcripts in all Hodgkin and Reed- Sternberg (H-RS) cells, and 18 of
these cases showed LMP expression exclusively in neoplastic cells. EBER+
small reactive cells were present in 39 cases in low numbers, and in three
cases in abundance. Thus, presence of H-RS cells with or without LMP
expression was not accompanied by an unrestricted proliferation of reactive
EBER+/LMP- lymphoid cells in the majority of HD patients. Simultaneous in
situ hybridization with [35S]-labeled immunoglobulin light chain (IgLC)
gene probes and nonisotopically labeled EBER probe showed a phenotype of
mature B lymphocytes and a polyclonal composition for a large proportion of
the EBER+ small cells. However, in contrast to noninfected cells, CD20
expression was not detectable in many of these cells, which may indicate
downregulation of certain differentiation antigens in latently EBV-infected
small lymphoid cells in vivo.
Volume 80,
Issue 2,
pp. 484-491,
07/15/1992
Copyright © 1992 by The American Society of Hematology
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