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Phenotypical characteristics of acute myelocytic leukemia associated with
the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of
immature B-cell antigen CD19 together with stem cell antigen CD34
K Kita, K Nakase, H Miwa, M Masuya, K Nishii, N Morita, N Takakura, A Otsuji, S Shirakawa and T Ueda
Second Department of Internal Medicine, Mie University School of Medicine,
Tsu, Japan.
Twenty-three acute myelocytic leukemia (AML) patients with t(8;21)
chromosomal abnormality, all classified as M2 (French-American-British
[FAB] classification), were investigated. Blastic cells from all patients
were positive for the stem cell-associated antigens, CD34 and HLA-DR, and
the immature myeloid antigens, CD13 and CD33. The nonblastic leukemic cells
expressed the more mature myeloid antigens, CD11b and CD15, with loss of
the immature phenotype. The incidence of positivities for the stem
cell-associated antigens, CD34 and HLA-DR, in t(8;21) AML cells was
significantly higher in comparison with those in other AML showing
granulocytic differentiation (M2 or M3). AML cells with t(8;21) also showed
some phenotypic abnormalities. Frequent expression of CD19 was found in the
blastic population of t(8;21) AML (18 of 23 cases) without other B-cell
antigens and Ig gene rearrangements. CD19 expression was confirmed by
immunocytochemistry and Northern blotting. The CD19+ blastic cells
coexpressed both CD34 and HLA-DR. In addition, CD33+ cells among the
blastic fraction in t(8;21) AML cells were fewer in number than in those of
M2 or M3 AML without t(8;21). Our findings indicate that leukemic blasts of
t(8;21) AML commonly express CD19 while preserving the stem cell-associated
antigens, and differentiate into the granulocytic pathway with discordant
maturation such as low CD33 expression.
Volume 80,
Issue 2,
pp. 470-477,
07/15/1992
Copyright © 1992 by The American Society of Hematology
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