|
|
 Previous Article | Table of Contents | Next Article 
Apoptotic cell death of primed CD45RO+ T lymphocytes in Epstein-Barr
virus-induced infectious mononucleosis
T Uehara, T Miyawaki, K Ohta, Y Tamaru, T Yokoi, S Nakamura and N Taniguchi
Department of Pediatrics, School of Medicine, Kanazawa University,
Ishikawa, Japan.
The expansion of activated T cells, characterized by the expression of
CD45RO as well as HLA-DR antigens, is a central feature in acute infectious
mononucleosis (IM) induced by primary infection of Epstein- Barr virus
(EBV). However, the fate of these activated T cells in this disease is not
clearly understood. We found that, on simple culture, a large proportion of
T cells isolated from acute IM patients died rapidly, but only a few T
cells from normal individuals did. Morphologic observations and DNA
fragmentation analysis showed that the loss of viability of IM T cells
after incubation was mediated by apoptosis. IM T cells undergoing apoptosis
resided exclusively in the CD45RO+ populations of both CD4+ and CD8+ T
cells, most of which were shown to coexpress apoptosis-related Fas antigen.
Some cytokines such as interleukin-2 (IL-2), IL-5, and IL-6 could rescue IM
T cells from apoptotic cell death. The results seemed to imply that most of
primed (CD45RO+) T cells in acute IM might be subject to apoptotic cell
death, possibly when leaving from the local sites actively producing
certain soluble factors required for their survival. Our studies suggest
the programmed cell death of peripheral mature T cells as a mechanism of
antigen-driven selection.
Volume 80,
Issue 2,
pp. 452-458,
07/15/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K. Shinozaki, H. Kanegane, H. Matsukura, R. Sumazaki, M. Tsuchida, M. Makita, Y. Kimoto, R. Kanai, K. Tsumura, T. Kondoh, et al.
Activation-dependent T cell expression of the X-linked lymphoproliferative disease gene product SLAM-associated protein and its assessment for patient detection
Int. Immunol.,
October 1, 2002;
14(10):
1215 - 1223.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Ryon, W. J. Moss, M. Monze, and D. E. Griffin
Functional and Phenotypic Changes in Circulating Lymphocytes from Hospitalized Zambian Children with Measles
Clin. Vaccine Immunol.,
September 1, 2002;
9(5):
994 - 1003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Dunne, J. M. Faint, N. H. Gudgeon, J. M. Fletcher, F. J. Plunkett, M. V. D. Soares, A. D. Hislop, N. E. Annels, A. B. Rickinson, M. Salmon, et al.
Epstein-Barr virus-specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential
Blood,
July 18, 2002;
100(3):
933 - 940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Uda, T. Mima, N. Yamaguchi, Y. Katada, M. Fukuda, N. Fujii, K. Nakamura, and O. Saiki
Expansion of a CD28-Intermediate Subset among CD8 T Cells in Patients with Infectious Mononucleosis
J. Virol.,
June 5, 2002;
76(13):
6602 - 6608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sauce, M. Bodinier, M. Garin, B. Petracca, N. Tonnelier, A. Duperrier, J. V. Melo, J. F. Apperley, C. Ferrand, P. Herve, et al.
Retrovirus-mediated gene transfer in primary T lymphocytes impairs their anti-Epstein-Barr virus potential through both culture-dependent and selection process-dependent mechanisms
Blood,
February 15, 2002;
99(4):
1165 - 1173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Hislop, N. H. Gudgeon, M. F. C. Callan, C. Fazou, H. Hasegawa, M. Salmon, and A. B. Rickinson
EBV-Specific CD8+ T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function
J. Immunol.,
August 15, 2001;
167(4):
2019 - 2029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Hviid, K. Kemp;, P. Kern, N. Wellinghausen;, J. Matsumoto, S. Kawai, and K. Terao
What Is the Cause of Lymphopenia in Malaria?
Infect. Immun.,
October 1, 2000;
68(10):
6087 - 6089.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. F. Fagnoni, R. Vescovini, G. Passeri, G. Bologna, M. Pedrazzoni, G. Lavagetto, A. Casti, C. Franceschi, M. Passeri, and P. Sansoni
Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging
Blood,
May 1, 2000;
95(9):
2860 - 2868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Zamanian-Daryoush, T. H. Mogensen, J. A. DiDonato, and B. R. G. Williams
NF-kappa B Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-kappa B-Inducing Kinase and Ikappa B Kinase
Mol. Cell. Biol.,
February 15, 2000;
20(4):
1278 - 1290.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. H. Dreyfus, M. Nagasawa, J. C. Pratt, C. A. Kelleher, and E. W. Gelfand
Inactivation of NF-{kappa}B by EBV BZLF-1-Encoded ZEBRA Protein in Human T Cells
J. Immunol.,
December 1, 1999;
163(11):
6261 - 6268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hoshino, T. Morishima, H. Kimura, K. Nishikawa, T. Tsurumi, and K. Kuzushima
Antigen-Driven Expansion and Contraction of CD8+-Activated T Cells in Primary EBV Infection
J. Immunol.,
November 15, 1999;
163(10):
5735 - 5740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Tanner and C. Alfieri
Epstein-Barr Virus Induces Fas (CD95) in T Cells and Fas Ligand in B Cells Leading to T-Cell Apoptosis
Blood,
November 15, 1999;
94(10):
3439 - 3447.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mathew, I. Kurane, S. Green, D. W. Vaughn, S. Kalayanarooj, S. Suntayakorn, F. A. Ennis, and A. L. Rothman
Impaired T Cell Proliferation in Acute Dengue Infection
J. Immunol.,
May 1, 1999;
162(9):
5609 - 5615.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Casoli, M. C. Re, P. Monari, G. Furlini, G. Tosi, C. Gradozzi, P. P. Dall'Aglio, U. Bertazzoni, and R. S. Accolla
Human T-Cell Leukemia Virus Type II Directly Acts on CD34+ Hematopoietic Precursors by Increasing Their Survival Potential. Envelope-Associated HLA Class II Molecules Reverse This Effect
Blood,
April 1, 1998;
91(7):
2296 - 2304.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Yasukawa, Y Inoue, H Ohminami, K Terada, and S Fujita
Apoptosis of CD4+ T lymphocytes in human herpesvirus-6 infection
J. Gen. Virol.,
January 1, 1998;
79(1):
143 - 147.
[Abstract]
|
|
|
|
|
|
|
P. Secchiero, L. Flamand, D. Gibellini, E. Falcieri, I. Robuffo, S. Capitani, R. C. Gallo, and G. Zauli
Human Herpesvirus 7 Induces CD4+ T-Cell Death by Two Distinct Mechanisms: Necrotic Lysis in Productively Infected Cells and Apoptosis in Uninfected or Nonproductively Infected Cells
Blood,
December 1, 1997;
90(11):
4502 - 4512.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Varadhachary, S. N. Perdow, C. Hu, M. Ramanarayanan, and P. Salgame
Differential ability of T cell subsets to undergo activation-induced cell death
PNAS,
May 27, 1997;
94(11):
5778 - 5783.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Tripp, A. M. Hamilton-Easton, R. D. Cardin, P. Nguyen, F. G. Behm, D. L. Woodland, P. C. Doherty, and M. A. Blackman
Pathogenesis of an Infectious Mononucleosis-like Disease Induced by a Murine gamma -Herpesvirus: Role for a Viral Superantigen?
J. Exp. Med.,
May 5, 1997;
185(9):
1641 - 1650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Gougeon and L. Montagnier
Response
Science,
November 26, 1993;
262(5138):
1356 - 1357.
[PDF]
|
|
|
|
|
|
|
A. D. Hislop, N. E. Annels, N. H. Gudgeon, A. M. Leese, and A. B. Rickinson
Epitope-specific Evolution of Human CD8+ T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection
J. Exp. Med.,
April 1, 2002;
195(7):
893 - 905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
