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Expression of the novel intermediate filament-associated protein restin in
Hodgkin's disease and anaplastic large-cell lymphoma
J Delabie, R Shipman, J Bruggen, B De Strooper, F van Leuven, L Tarcsay, N Cerletti, K Odink, V Diehl and G Bilbe
Laboratory of Histochemistry and Cytochemistry, Catholic University of
Leuven, Belgium.
In this study, the expression of the novel intermediate filament protein
Restin in human tissues was analyzed. Restin expression was studied by
immunohistochemistry using polyclonal and monoclonal antibodies. Restin was
not detected in normal tissues, a range of B- and T-cell non-Hodgkin's
lymphomas, and nonlymphoid tumors. However, Restin was present in
Reed-Sternberg cells and variants thereof in Hodgkin's disease, with the
exception of the lymphocyte-predominant, paragranuloma subtype. Restin was
also highly expressed in anaplastic large-cell lymphoma (so-called Ki-1
lymphoma). As expected, Restin was also expressed in Hodgkin cell lines
L428, L428KSA, Co, and KM-H2 and the anaplastic large-cell lymphoma cell
line Karpas 299, which was confirmed by sodium dodecyl
sulfate-polyacrylamide gel electrophoresis and Western blotting, as well as
Northern blotting. The presence of Restin in both Hodgkin's disease and
anaplastic large-cell lymphoma is intriguing and might indicate a role of
this structural protein in the pathogenesis of both conditions.
Volume 80,
Issue 11,
pp. 2891-2896,
12/01/1992
Copyright © 1992 by The American Society of Hematology
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