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Human peritoneal mesothelial cells produce many cytokines (granulocyte
colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage- CSF,
interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by
IL-1
L Lanfrancone, D Boraschi, P Ghiara, B Falini, F Grignani, G Peri, A Mantovani and PG Pelicci
Istituto Clinica Medica I, Universita di Perugia, Italy.
To investigate the role of peritoneal mesothelial cells in regulating
hematopoiesis, as well as inflammation, healing, and tissue regeneration
processes, long-term cultures of peritoneal mesothelial cells from human
endocavitarian fluids were established. The purity of the cell population
was assessed by morphologic and immunocytochemical criteria. Five
peritoneal mesothelial cell cultures were analyzed for cytokine expression.
Macrophage colony-stimulating factor (M-CSF), granulocyte-CSF (G-CSF),
interleukin-1 alpha (IL-1 alpha), IL-1 beta, and IL-6 transcripts were
constantly but variably detected throughout the culture period, while
granulocyte-monocyte-CSF (GM-CSF) expression started as the cell culture
aged. No IL-2, IL-3, IL-4, IL-5, or IL-7 transcripts were detected in the
same samples. Corresponding cytokine activities were detected in the
supernatants of the cultures. Peritoneal mesothelial cells proliferated
after the addition of exogenous IL-1 beta or IL-1 alpha, whereas the
addition of recombinant GM-CSF, G-CSF, M-CSF, or IL-6 failed to trigger
proliferation. IL-1 receptor type I transcripts were detected in peritoneal
mesothelial cells. Moreover, IL-1 was able to upregulate the expression of
the genes that code for G-CSF, GM-CSF, IL-1 alpha, and IL-1 beta in these
cells. These data indicate that peritoneal mesothelial cells produce many
cytokines and suggest that IL-1 is a regulatory molecule for peritoneal
mesothelial cells.
Volume 80,
Issue 11,
pp. 2835-2842,
12/01/1992
Copyright © 1992 by The American Society of Hematology
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