|
|
 Previous Article | Table of Contents | Next Article 
Tumor necrosis factor and interleukin-1 induce expression of the
verocytotoxin receptor globotriaosylceramide on human endothelial cells:
implications for the pathogenesis of the hemolytic uremic syndrome
NC van de Kar, LA Monnens, MA Karmali and VW van Hinsbergh
Gaubius Laboratory, IVVO-TNO, Leiden, The Netherlands.
The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an
acute gastroenteritis, has been associated with a verocytotoxin- producing
Escherichia coli infection. The endothelial cell is believed to play an
important role in the pathogenesis of HUS. Endothelial cell damage by
verocytotoxin-1 (VT-1) in vitro is potentiated by the additional exposure
of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha).
Preincubation of human umbilical vein endothelial cells (HUVEC) with
TNF-alpha resulted in a 10- to 100-fold increase of specific binding sites
for 125I-VT-1. Furthermore, interleukin-1 (IL-1), lymphotoxin (TNF-beta),
and lipopolysaccharide (LPS) also markedly increase VT-1 binding. Several
hours' exposure to TNF-alpha was enough to enhance the number of VT-1
receptors on the endothelial cells for 2 days. The TNF-alpha-induced
increase in VT-1 binding could be inhibited by simultaneous addition of the
protein synthesis inhibitor cycloheximide. Glycolipid extracts of
TNF-alpha- treated cells tested on thin-layer chromatography demonstrated
an increase of globotriaosylceramide (GbOse3cer), a functional receptor for
VT-1, which suggests that preincubation of human endothelial cells with
TNF-alpha leads to an increase in GbOse3cer synthesis in these cells. We
conclude from this study that TNF-alpha and IL-1 induce one (or more)
enzyme(s) that is (are) rate-limiting in the synthesis of the glycolipid
VT-1 receptor, GbOse3cer. These in vitro studies suggest that, in addition
to VT-1, inflammatory mediators play an important role in the pathogenesis
of HUS.
Volume 80,
Issue 11,
pp. 2755-2764,
12/01/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
T. Okuda and K.-i. Nakayama
Identification and characterization of the human Gb3/CD77 synthase gene promoter
Glycobiology,
December 1, 2008;
18(12):
1028 - 1035.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Poirier, S. P. Faucher, M. Beland, R. Brousseau, V. Gannon, C. Martin, J. Harel, and F. Daigle
Escherichia coli O157:H7 Survives within Human Macrophages: Global Gene Expression Profile and Involvement of the Shiga Toxins
Infect. Immun.,
November 1, 2008;
76(11):
4814 - 4822.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. K. Stone, G. L. Kolling, M. H. Lindner, and T. G. Obrig
p38 Mitogen-Activated Protein Kinase Mediates Lipopolysaccharide and Tumor Necrosis Factor Alpha Induction of Shiga Toxin 2 Sensitivity in Human Umbilical Vein Endothelial Cells
Infect. Immun.,
March 1, 2008;
76(3):
1115 - 1121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-Y. Lee, R. P. Cherla, and V. L. Tesh
Simultaneous Induction of Apoptotic and Survival Signaling Pathways in Macrophage-Like THP-1 Cells by Shiga Toxin 1
Infect. Immun.,
March 1, 2007;
75(3):
1291 - 1302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. R. Keepers, L. K. Gross, and T. G. Obrig
Monocyte Chemoattractant Protein 1, Macrophage Inflammatory Protein 1{alpha}, and RANTES Recruit Macrophages to the Kidney in a Mouse Model of Hemolytic-Uremic Syndrome
Infect. Immun.,
March 1, 2007;
75(3):
1229 - 1236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Okuda, N. Tokuda, S.-i. Numata, M. Ito, M. Ohta, K. Kawamura, J. Wiels, T. Urano, O. Tajima, K. Furukawa, et al.
Targeted Disruption of Gb3/CD77 Synthase Gene Resulted in the Complete Deletion of Globo-series Glycosphingolipids and Loss of Sensitivity to Verotoxins
J. Biol. Chem.,
April 14, 2006;
281(15):
10230 - 10235.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. P. Cherla, S.-Y. Lee, P. L. Mees, and V. L. Tesh
Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line
J. Leukoc. Biol.,
February 1, 2006;
79(2):
397 - 407.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Guessous, M. Marcinkiewicz, R. Polanowska-Grabowska, S. Kongkhum, D. Heatherly, T. Obrig, and A. R. L. Gear
Shiga Toxin 2 and Lipopolysaccharide Induce Human Microvascular Endothelial Cells To Release Chemokines and Factors That Stimulate Platelet Function
Infect. Immun.,
December 1, 2005;
73(12):
8306 - 8316.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. T. Yamamoto, M. Mizuno, K. Nishikawa, S. Miyazawa, L. Zhang, S. Matsuo, and Y. Natori
Shiga Toxin 1 Causes Direct Renal Injury in Rats
Infect. Immun.,
November 1, 2005;
73(11):
7099 - 7106.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-Y. Lee, R. P. Cherla, I. Caliskan, and V. L. Tesh
Shiga Toxin 1 Induces Apoptosis in the Human Myelogenous Leukemia Cell Line THP-1 by a Caspase-8-Dependent, Tumor Necrosis Factor Receptor-Independent Mechanism
Infect. Immun.,
August 1, 2005;
73(8):
5115 - 5126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Harrison, C. van den Hoogen, W. C. E. van Haaften, and V. L. Tesh
Chemokine Expression in the Monocytic Cell Line THP-1 in Response to Purified Shiga Toxin 1 and/or Lipopolysaccharides
Infect. Immun.,
January 1, 2005;
73(1):
403 - 412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tzipori, A. Sheoran, D. Akiyoshi, A. Donohue-Rolfe, and H. Trachtman
Antibody Therapy in the Management of Shiga Toxin-Induced Hemolytic Uremic Syndrome
Clin. Microbiol. Rev.,
October 1, 2004;
17(4):
926 - 941.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Harrison, W. C. E. van Haaften, and V. L. Tesh
Regulation of Proinflammatory Cytokine Expression by Shiga Toxin 1 and/or Lipopolysaccharides in the Human Monocytic Cell Line THP-1
Infect. Immun.,
May 1, 2004;
72(5):
2618 - 2627.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Nakamura, A. Imaizumi, Y. Yanagawa, T. Kohsaka, and E. J. Johns
{beta}2-Adrenoceptor Activation Attenuates Endotoxin-Induced Acute Renal Failure
J. Am. Soc. Nephrol.,
February 1, 2004;
15(2):
316 - 325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Westerholt, A.-K. Pieper, M. Griebel, H.-D. Volk, T. Hartung, and R. Oberhoffer
Characterization of the Cytokine Immune Response in Children Who Have Experienced an Episode of Typical Hemolytic-Uremic Syndrome
Clin. Vaccine Immunol.,
November 1, 2003;
10(6):
1090 - 1095.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yoshida, T. Sugiyama, N. Koide, I. Mori, and T. Yokochi
Human microvascular endothelial cells resist Shiga toxins by IFN-{gamma} treatment in vitro
Microbiology,
September 1, 2003;
149(9):
2609 - 2614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yuhas, A. Weizman, and S. Ashkenazi
Bidirectional Concentration-Dependent Effects of Tumor Necrosis Factor Alpha in Shigella dysenteriae-Related Seizures
Infect. Immun.,
April 1, 2003;
71(4):
2288 - 2291.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. Menge, I. Stamm, M. Blessenohl, L. H. Wieler, and G. Baljer
Verotoxin 1 from Escherichia coli Affects Gb3/CD77+ Bovine Lymphocytes Independent of Interleukin-2, Tumor Necrosis Factor-{alpha}, and Interferon-{alpha}
Experimental Biology and Medicine,
April 1, 2003;
228(4):
377 - 386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. G. Obrig, R. M. Seaner, M. Bentz, C. A. Lingwood, B. Boyd, A. Smith, and W. Narrow
Induction by Sphingomyelinase of Shiga Toxin Receptor and Shiga Toxin 2 Sensitivity in Human Microvascular Endothelial Cells
Infect. Immun.,
February 1, 2003;
71(2):
845 - 849.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Cameron, D. Bingham, A. Paul, M. Pavelka, S. Cameron, D. Rotondo, and R. Plevin
Essential Role for Verotoxin in Sustained Stress-Activated Protein Kinase and Nuclear Factor Kappa B Signaling, Stimulated by Escherichia coli O157:H7 in Vero Cells
Infect. Immun.,
October 1, 2002;
70(10):
5370 - 5380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Hughes, Z. Ergonul, P. K. Stricklett, and D. E. Kohan
Molecular Basis for High Renal Cell Sensitivity to the Cytotoxic Effects of Shigatoxin-1: Upregulation of Globotriaosylceramide Expression
J. Am. Soc. Nephrol.,
September 1, 2002;
13(9):
2239 - 2245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. H. Foster and V. L. Tesh
Shiga toxin 1-induced activation of c-Jun NH2-terminal kinase and p38 in the human monocytic cell line THP-1: possible involvement in the production of TNF-{alpha}
J. Leukoc. Biol.,
January 1, 2002;
71(1):
107 - 114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. NAKAMURA, E. J. JOHNS, A. IMAIZUMI, Y. YANAGAWA, and T. KOHSAKA
Activation of {beta}2-Adrenoceptor Prevents Shiga Toxin 2-Induced TNF-{alpha} Gene Transcription
J. Am. Soc. Nephrol.,
November 1, 2001;
12(11):
2288 - 2299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Morigi, M. Galbusera, E. Binda, B. Imberti, S. Gastoldi, A. Remuzzi, C. Zoja, and G. Remuzzi
Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress
Blood,
September 15, 2001;
98(6):
1828 - 1835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Karpman, D. Papadopoulou, K. Nilsson, A.-C. Sjogren, C. Mikaelsson, and S. Lethagen
Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome
Blood,
May 15, 2001;
97(10):
3100 - 3108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. J. M. PIJPERS, P. A. V. SETTEN, L. P. W. J. V. D. HEUVEL, K. J. M. ASSMANN, H. B. P. M. DIJKMAN, A. H. M. PENNINGS, L. A. H. MONNENS, and V. W. M. V. HINSBERGH
Verocytotoxin-Induced Apoptosis of Human Microvascular Endothelial Cells
J. Am. Soc. Nephrol.,
April 1, 2001;
12(4):
767 - 778.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. W. M. TE LOO, V. W. M. V. HINSBERGH, L. P. W. J. V. D. HEUVEL, and L. A. H. MONNENS
Detection of Verocytotoxin Bound to Circulating Polymorphonuclear Leukocytes of Patients with Hemolytic Uremic Syndrome
J. Am. Soc. Nephrol.,
April 1, 2001;
12(4):
800 - 806.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Memon, W. M. Holleran, Y. Uchida, A. H. Moser, C. Grunfeld, and K. R. Feingold
Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin
J. Lipid Res.,
March 1, 2001;
42(3):
452 - 459.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. B. Eisenhauer, P. Chaturvedi, R. E. Fine, A. J. Ritchie, J. S. Pober, T. G. Cleary, and D. S. Newburg
Tumor Necrosis Factor Alpha Increases Human Cerebral Endothelial Cell Gb3 and Sensitivity to Shiga Toxin
Infect. Immun.,
March 1, 2001;
69(3):
1889 - 1894.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. M. Wolski, A. M. Soltyk, and J. L. Brunton
Mouse Toxicity and Cytokine Release by Verotoxin 1 B Subunit Mutants
Infect. Immun.,
January 1, 2001;
69(1):
579 - 583.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. SUZUKI, K. TATEDA, T. MATSUMOTO, F. GONDAIRA, S. TSUJIMOTO, and K. YAMAGUCHI
Effects of interaction between Escherichia coli verotoxin and lipopolysaccharide on cytokine induction and lethality in mice
J. Med. Microbiol.,
October 1, 2000;
49(10):
905 - 910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. H. Foster, C. S. Armstrong, R. Sakiri, and V. L. Tesh
Shiga Toxin-Induced Tumor Necrosis Factor Alpha Expression: Requirement for Toxin Enzymatic Activity and Monocyte Protein Kinase C and Protein Tyrosine Kinases
Infect. Immun.,
September 1, 2000;
68(9):
5183 - 5189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Matise, T. Sirinarumitr, B. T. Bosworth, and H. W. Moon
Vascular Ultrastructure and DNA Fragmentation in Swine Infected with Shiga Toxin-Producing Escherichia coli
Vet. Pathol.,
July 1, 2000;
37(4):
318 - 327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. W. M. te Loo, L. A. H. Monnens, T. J. A. M. van der Velden, M. A. Vermeer, F. Preyers, P. N. M. Demacker, L. P. W. J. van den Heuvel, and V. W. M. van Hinsbergh
Binding and transfer of verocytotoxin by polymorphonuclear leukocytes in hemolytic uremic syndrome
Blood,
June 1, 2000;
95(11):
3396 - 3402.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Laithwaite, S. J. Benn, J. Yamate, D. J. FitzGerald, and J. LaMarre
Enhanced Macrophage Resistance to Pseudomonas Exotoxin A Is Correlated with Decreased Expression of the Low-Density Lipoprotein Receptor-Related Protein
Infect. Immun.,
November 1, 1999;
67(11):
5827 - 5833.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.C. LaCasse, M.R. Bray, B. Patterson, W.-M. Lim, S. Perampalam, L. G. Radvanyi, A. Keating, A.K. Stewart, R. Buckstein, J.S. Sandhu, et al.
Shiga-Like Toxin-1 Receptor on Human Breast Cancer, Lymphoma, and Myeloma and Absence From CD34+ Hematopoietic Stem Cells: Implications for Ex Vivo Tumor Purging and Autologous Stem Cell Transplantation
Blood,
October 15, 1999;
94(8):
2901 - 2910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Menge, L. H. Wieler, T. Schlapp, and G. Baljer
Shiga Toxin 1 from Escherichia coli Blocks Activation and Proliferation of Bovine Lymphocyte Subpopulations In Vitro
Infect. Immun.,
May 1, 1999;
67(5):
2209 - 2217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. B. Taylor Jr., V. L. Tesh, L. DeBault, A. Li, A. C. K. Chang, S. D. Kosanke, T. J. Pysher, and R. L. Siegler
Characterization of the Baboon Responses to Shiga-Like Toxin : Descriptive Study of a New Primate Model of Toxic Responses to Stx-1
Am. J. Pathol.,
April 1, 1999;
154(4):
1285 - 1299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yuhas, L. Shulman, A. Weizman, E. Kaminsky, A. Vanichkin, and S. Ashkenazi
Involvement of Tumor Necrosis Factor Alpha and Interleukin-1beta in Enhancement of Pentylenetetrazole-Induced Seizures Caused by Shigella dysenteriae
Infect. Immun.,
March 1, 1999;
67(3):
1455 - 1460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. L. W. Cooling, K. E. Walker, T. Gille, and T. A. W. Koerner
Shiga Toxin Binds Human Platelets via Globotriaosylceramide (Pk Antigen) and a Novel Platelet Glycosphingolipid
Infect. Immun.,
September 1, 1998;
66(9):
4355 - 4366.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Sakiri, B. Ramegowda, and V. L. Tesh
Shiga Toxin Type 1 Activates Tumor Necrosis Factor-alpha Gene Transcription and Nuclear Translocation of the Transcriptional Activators Nuclear Factor-kappa B and Activator Protein-1
Blood,
July 15, 1998;
92(2):
558 - 566.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Paton and A. W. Paton
Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections
Clin. Microbiol. Rev.,
July 1, 1998;
11(3):
450 - 479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
