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Hepatocyte growth factor is a synergistic factor for the growth of
hematopoietic progenitor cells
TE Kmiecik, JR Keller, E Rosen and GF Vande Woude
ABL-Basic Research Program, Program Resources, Inc/DynCorp, Inc, National
Cancer Institute-Frederick Cancer Research and Development Center, MD
21701.
Bone marrow (BM) stromal cells, which include macrophages, fibroblasts,
endothelial cells, and adipocytes, have been shown to produce several
factors that modulate the growth of BM progenitors. Hepatocyte growth
factor (HGF) is a fibroblast-derived factor and has recently been shown to
be a ligand for the c-met proto-oncogene, a member of the receptor class of
tyrosine kinases. c-met messenger RNA (mRNA) is predominantly expressed in
epithelial cells, but has been detected in several murine hematopoietic
progenitor cell lines, suggesting that HGF and met might function during
hematopoiesis. Here, BM cells were found to express both met mRNA and
protein. Moreover, HGF was shown to synergize with interleukin-3 and
granulocyte-macrophage colony-stimulating factor to stimulate colony
formation of hematopoietic progenitor cells in vitro. These results show
that, in addition to its activity on epithelial cells, HGF is a new member
of the functionally related group of factors that modulate hematopoiesis.
Volume 80,
Issue 10,
pp. 2454-2457,
11/15/1992
Copyright © 1992 by The American Society of Hematology
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