Blood, 1953, Vol. 8, No. 7, pp. 655-660.
© 1953 American Society of Hematology, Inc.
The Effect of a Series of Ethylenimine Derivatives on
Myeloid Chloroleukemia in the Rat
SARAH J. SPARKS B.S.1,
MARION L. STEVENS B.S.1,
M. JANE LANDES A.B.1,
SYBELLA L. HALLIDAY A.B.1,
DORIS McKENZIE M.S.1,
JAMES H. WILLIAMS PH.D.1, and
LAWRENCE SEBASTIANELLI 1
1 Lederle Laboratories Division. American Cyanamid Company, Pearl River,
N. Y.
A myeloid chloroleukemia in the rat has been studied and developed into an
assay for the screening of antileukemic compounds.
A series of phosphoramide derivatives have been found to be effective against
this leukemia, and comparative studies on their activity have been made. These
compounds appear to be as effective as TEM and can be administered at higher
dosage levels. All of the compounds produced a prompt remission of the disease.
Submitted on October 10, 1952
Accepted on March 29, 1953
