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Blood, 1953, Vol. 8, No. 7, pp. 620-639.
© 1953 American Society of Hematology, Inc.

Hemolytic Disease of the Newborn Due to Anti-A

HAL CRAWFORD B.SC.1, MARIE CUTBUSH B.SC.1, and P. L. MOLLISON M.D., M.R.C.P.1

1 Medical Research Council's Blood Transfusion Research Unit, Postgraduate Medical School, London, W. 12, England.

Eleven cases of hemolytic disease of the newborn are described in which the only blood group antibody in the mother's serum, incompatible with the infant's cells, was anti-A. The direct antiglobulin (Coombs) test on the infant's red cells was weakly positive in 7 cases and negative in 4 cases. In every case the mother's serum displayed immune characteristics, in particular the ability to lyse A cells.

Osmotic fragility was increased in 10 out of 11 cases. This finding is contrasted with those in a series of cases of hemolytic disease of the newborn due to anti-Rh.

Submitted on November 22, 1952
Accepted on December 15, 1952


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