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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by FRICK, P. G. Search for Related Content PubMed PubMed Citation Articles by FRICK, P. G. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1953, Vol. 8, No. 7, pp. 598-608. © 1953 American Society of Hematology, Inc. Hemophilia-like Disease Following Pregnancy With Transplacental Transfer of an Acquired Circulating Anticoagulant PAUL G. FRICK M.D.1 1 Department of Medicine, University of Minnesota Hospital, Minneapolis, Minn. 1. A hemophilia-like disease acquired during the first pregnancy of a young woman, is described. 2. The clotting abnormality was caused by a circulating anticoagulant which, in all probability, inhibited the antihemophilic globulin. 3. The anticoagulant was demonstrated in the patient's second child during his first two and one-half months of life. 4. The transplacental transfer of the anticoagulant and the analogy of this condition to hemophilia (resistant to therapy) following iso-immunization against antihemophilic globulin, strongly suggest that an immunologic mechanism accounts for the development of this abnormality. 5. The patient recovered eighteen months after her second delivery and sixteen months after x-ray sterilization. The possible relation between endocrine factors and recovery is discussed. Submitted on November 22, 1952 Accepted on February 16, 1953 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. J. Michiels Acquired Hemophilia A in Women Postpartum: Clinical Manifestations, Diagnosis, and Treatment Clinical and Applied Thrombosis/Hemostasis, April 1, 2000; 6(2): 82 - 86. [Abstract] [PDF]

	Copyright © 1953 by American Society of Hematology         Online ISSN: 1528-0020