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Blood, 1953, Vol. 8, No. 6, pp. 554-562.
© 1953 American Society of Hematology, Inc.

Proteolytic and Fibrinolytic Activity of Serum

Activation by Streptokinase and Staphylokinase Indicating Dissimilarity of Enzymes

EUGENE E. CLIFFTON M.D.1 and DOLLY A. CANNAMELA B.S.1

1 Department of Surgery (Oncology) Yale University School of Medicine, New Haven, Conn.

1. The fibrinolytic and proteolytic activity of serum plasminogen, activated by Streptokinase and Staphylokinase and measured by clot lysis and casein digestion, was studied in the following species of animals: human, cow, dog, horse, monkey, pig, rabbit, rat, and chicken.

2. A significant difference in fibrinolytic and proteolytic activity of serum plasminogen (activated by staphylokinase) was observed in three animal species: monkey, horse, and human. The significance of this observation is briefly discussed.

Submitted on October 22, 1952
Accepted on January 26, 1953


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