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Blood, 1953, Vol. 8, No. 4, pp. 349-357.
© 1953 American Society of Hematology, Inc.
Humoral Regulation of Red Cell Production
ALLAN ERSLEV M.D.1
1 Department of Internal Medicine, Yale University School of Medicine, New
Haven, Conn.
Large amounts of plasma from rabbits, rendered anemic by bleeding, were
injected into normal rabbits. A significant rise in the number of reticulocytes was
observed in these rabbits. Control rabbits receiving the same amount of plasma
from normal donor rabbits failed to show any significant change in the reticulocyte count. A definite increase in red blood cell count, hematocrit and per cent
nucleated red cells of the bone marrow was noticed in 2 rabbits receiving repeated injections of plasma from anemic rabbits. It is concluded that plasma from
rabbits rendered anemic by bleeding contains a factor capable of stimulating
red cell production.
Submitted on October 28, 1952
Accepted on December 1, 1952
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