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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by WILLIAMS, M. J. Articles by CLAPP, M. P. Search for Related Content PubMed PubMed Citation Articles by WILLIAMS, M. J. Articles by CLAPP, M. P. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1953, Vol. 8, No. 4, pp. 336-341. © 1953 American Society of Hematology, Inc. Action of Alpha-Tocopherol Phosphate on Hemolysis in Paroxysmal Nocturnal Hemoglobinuria MARJORIE J. WILLIAMS M.B., CH.B. (BRIST.)1 and MARY P. CLAPP M.S.1 1 Laboratory Service, Veterans Administration Center, Temple, Texas. 1. The action of alpha-tocopherol phosphate (TPO4), an anticoagulant, on PNH hemolysis was studied by both in vitro and in vivo means. It was found that the addition of TPO4 to the modified Ham test inhibited lysis of PNH erythrocytes. During the intramuscular administration of TPO4, the susceptibility of the erythrocytes to lysis by fresh acidified serum progressively decreased. These cells, after incubation with the serum, gave a positive Coombs test. 2. The possible significance of these findings is briefly discussed. 3. It is concluded that TPO4 has no therapeutic value in PNH. Submitted on August 19, 1952 Accepted on October 30, 1952 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1953 by American Society of Hematology         Online ISSN: 1528-0020