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1 Laboratory of Experimental Oncology, National Cancer Institute, National
Institutes of Health, Public Health Service, Federal Security Agency and the Divisions of
Surgery and Medicine and the Cancer Research Institute, University of California School
of Medicine, San Francisco, Calif.
1. The leukocyte content of femoral arterial and venous blood was determined
simultaneously following the administration of 0.1 to 0.3 mg. of histamine (as
base) directly into the femoral artery in 5 patients at rates varying from 1.1 to
6.7 µg. per second. 2. A marked and prompt decrease in leukocyte number was found in the blood
from the femoral vein of the same leg after the histamine infusion started; this
preceded the changes in the blood from the femoral artery. 3. The discrepancy between the venous and arterial counts indicates the withdrawal of leukocytes within the circulation of the lower extremity which is generally related to the rate and amount of histamine administered. 4. In 6 patients, histamine (0.15 to 0.4 mg.) was administered directly into
the aorta at levels from T3 to L2. In five of nine instances, blood from the pulmonary artery or inferior vena cava initially showed a prompt fall in leukocyte
number, which exceeded the leukopenia observed in blood sampled from the
aorta. In two instances, the leukocyte counts from the aorta exhibited no significant change. 5. The venous leukopenia following the administration of histamine into the
aorta probably occurs as a result of sequestration of leukocytes in the peripheral
capillaries which accompanies the arterial leukopenia due to a similar effect in
the pulmonary circulation.
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| Copyright © 1953 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
