Blood, 1953, Vol. 8, No. 4, pp. 295-314.
© 1953 American Society of Hematology, Inc.
The Myeloproliferative Disorders
With Special Reference to Myelofibrosis
M. S. R. HUTT M.D., M.R.C.P.1,
J. L. PINNIGER D.M., M.R.C.P.1, and
G. WETHERLEY-MEIN M.B., B.CHIR.1
1 Louis Jenner Laboratory, St. Thomas’s Hospital and Medical School London,
England.
1. The clinical, hematologic and histologic findings in 10 patients with primary
proliferative marrow disorders are presented.
2. It is considered that these findings indicate that myelofibrosis, myeloid
leukemia, megakaryocytic myelosis and probably polycythemia vera are similar
and related processes.
3. It is suggested that this relationship may be regarded as an example of a
proliferative or neoplastic process involving multipotential primitive mesenchymal cells.
4. The significance of splenomegaly in myelofibrosis, the nature of extramedullary hemopoiesis and the relationship between this group of marrow disorders
and the primary lymph node tumours are briefly discussed.
Submitted on September 23, 1952
Accepted on October 20, 1952
