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Blood, 1953, Vol. 8, No. 3, pp. 276-281.
© 1953 American Society of Hematology, Inc.

Studies on the Anticoagulant Phenylindanedione

I. The Effect of Emulsified Vitamin K1 on Phenylindanedione-Induced Hypoprothrombinemia

CHARLES G. GUTTAS M.D.1, WILLIAM C. MOLONEY M.D.1, and HERBERT S. SISE M.D.1

1 Clinical Research Laboratory, First and Third Medical Services (Tufts), Boston City Hospital and the Department of Medicine, Tufts College School of Medicine, Boston, Mass.

1. Phenylindanedione-induced hypoprothrombinemia is rapidly counteracted by a vitamin K1 emulsion. This hypoprothrombinemia is antagonized at a more rapid rate than that induced by any of the other commonly employed prothrombopenic agents.

2. The optimum dose of the vitamin K1 emulsion in emergency is 5 mg. per Kg. Since a refractoriness to the prothrombopenic action of phenylindanedione ensues, smaller doses should be used in situations where there is to emergency.

Submitted on September 29, 1952
Accepted on October 28, 1952


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