Blood, 1953, Vol. 8, No. 2, pp. 125-130.
© 1953 American Society of Hematology, Inc.
Researches on a Circulating Anticoagulant in a
Hemophiliac
II. Effect of Administration of ACTH and Cortisone
S. VAN CREVELD M.D.1,
P. G. HOORWEG M.D.1, and
M. M. P. PAULSSEN PH.D.1
1 Pediatric Clinic of the Municipal University of Amsterdam and the Central
Laboratory of the Blood transfusion Service of the Dutch Red Cross at Amsterdam.
The influence of the administration of ACTH and cortisone on a circulating
anticoagulant appearing after repeated blood transfusions in a hemophiliac was
studied. It was found that the activity of the anticoagulant was diminished to
a considerable degree, even though temporarily, and the clotting time was reduced by plasma transfusions more than prior to the administration of ACTH
and cortisone. Antibodies to the Duffy antigen were also present together with
the circulating anticoagulant, but their activity was not clearly affected by the
administration of ACTH and cortisone.
Submitted on April 30, 1952
Accepted on November 26, 1952
