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1 Division of Immunohematology of the Jewish Hospital of Brooklyn, Brooklyn,
N. Y., the Serological Laboratory of the Office of the Chief Medical Examiner of New York
City, New York, N. Y., and the Clinica Ostetrica e Ginecologica, Università di Napoli, Naples, Italy.
The distribution of the A-B-O blood groups among four hundred fifty-seven
sensitized Rh negative mothers was compared with the distribution among
eight hundred twenty-three nonsensitized Rh negative mothers. As expected, the
frequencies of groups O and B were lower while that of group A was higher in
the series of sensitized women. The difference in frequency of group A was 5
times its probable error and therefore statistically significant. Surprisingly,
however, the difference proved to be due entirely to subgroup A1, while the frequency of subgroup A2 was the same in both series. In a random series of four thousand nine hundred seventy-four Caucasoid
individuals in New York City, the frequency of type rh was found to be 0.95
per cent. Statistical analysis of the Rh types of four hundred fifty-seven sensitized Rh negative mothers indicates, on the other hand, that the frequency of
type rh is actually 0.41 per cent. The discrepancy is explained by postulating
that in the control series, about half of the supposed type rh individuals were
really type Rh1, since no special test had been made for Rh0 variants. In the
series of sensitized Rh negative mothers, individuals of type Rh1 are automatically
screened out since when factor Rh0 is present sensitization to the Rh0 factor is
hardly likely to occur.
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| Copyright © 1953 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||