Blood, 1953, Vol. 8, No. 10, pp. 923-933.
© 1953 American Society of Hematology, Inc.
Cyclic Neutropenia with Giant Follicular Lymphoblastoma
and Lymphosarcoma
Report of a Case with Splenectomy
ROBERT P. NATELSON CAPT., MC, USA1
1 Medical Service, William Beaumont Army Hospital, Fort Bliss, Tex.
1. A case of the rare disorder cyclic neutropenia with giant follicular lymphoblastoma and lymphosarcoma is reported.
2. Adrenocorticotropic hormone administration during a neutropenic phase
resulted in a further depression of the total leukocyte count and no significant
change in the already very low neutrophil count. Cortisone did not prevent or
ameliorate a recurrence of neutropenia.
3. Splenectomy resulted in less depression of the total leukocyte and neutrophil values and a considerable amelioration of the symptoms during the continued cycles; however, because of the short follow-up, a definite statement on
the long range value of splenectomy cannot be made.
4. The pathogenesis of cyclic neutropenia is discussed with particular reference to its relationship to lymphoma and hypersplenism.
Submitted on March 3, 1953
Accepted on April 6, 1953
