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Blood, 1953, Vol. 8, No. 1, pp. 65-71.
© 1953 American Society of Hematology, Inc.
The Demonstration of the "L.E." Phenomenon in
Patients with Penicillin Hypersensitivity
JOHN R. WALSH M.D.1 and
HYMAN J. ZIMMERMAN M.D.1
1 Department of Medicine, Veterans Administration Hospital, Omaha, Neb.,
and the Creighton University School of Medicine and University of Nebraska College of
Medicine.
Of 6 patients with penicillin reactions, 3 whose reactions were severe were
found to possess the "L. E." factor in the plasma and "L. E." cells in the bone
marrow. The 3 who failed to show the "L. E". phenomenon had only minimal
reactions to penicillin. Since the group studied was small, no conclusions regarding the incidence of the "L. E." phenomenon in penicillin reactions can be
drawn. The findings are discussed in the light of the possibility that the phenomenon may be related to hypersensitivity reactions as well as to systemic
lupus erythematosus.
Submitted on July 15, 1952
Accepted on October 8, 1952
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