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Tumor necrosis factor stimulates Na+/H+ antiporter in human fibroblasts: dissociation between intracellular alkalinization and cytokine mRNA accumulation

YY Lee, I Kurtz, K Yamato, Z el-Hajjoui and HP Koeffler

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Several hormones and cytokines stimulate the cellular Na+/H+ antiporter and this stimulation may be a signal transduction mechanism to mediate gene expression. We find that tumor necrosis factor rapidly stimulates both the Na+/H+ antiporter and the accumulation of mRNA coding for granulocyte-macrophage colony-stimulating factor and interleukin-6 in fibroblasts. Further experiments show that these phenomena occur independent of each other.

Volume 79, Issue 9, pp. 2262-2266, 05/01/1992
Copyright © 1992 by The American Society of Hematology


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