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Follicular lymphoma with t(8;14)(q24;q32): a distinct clinical and
molecular subset of t(8;14)-bearing lymphomas
M Ladanyi, K Offit, NZ Parsa, MR Condon, N Chekka, JP Murphy, DA Filippa, SC Jhanwar, R Dalla-Favera and RS Chaganti
Laboratory of Cancer Genetics, Sloan-Kettering Institute, Memorial
Sloan-Kettering Cancer Center, New York, NY 10021.
The presence of the translocation t(8;14)(q24;q32) has not been well
described in follicular lymphoma (FL). In a consecutive series of 278
karyotypically abnormal non-Hodgkin's lymphomas (NHL), six patients with FL
showing a t(8;14) without a t(14;18)(q32;q21) were identified. They ranged
in age from 45 to 73 years. The cell type was mixed in four patients,
small-cleaved in one, and large-cleaved in one; four cases also contained
diffuse areas. All cases tested displayed monoclonal surface Ig. The
clinical courses were consistent with the histologic subtypes, being less
aggressive than other t(8;14)-bearing NHL. In five cases, frozen tissue was
available for Southern blotting. The BCL2 gene showed a germline
configuration when studied with the MBR, MCR, and 5' cDNA probes. The MYC
gene also appeared unrearranged using an exon-1 probe with EcoRI or HindIII
digestion. Analysis of the Ig heavy chain (IgH) gene with a JH region probe
and BamHI or EcoRI digestion showed only one rearranged band in all cases,
indicating that the 14q32 breakpoint did not lie in either the J or
switch-mu (SM) regions. In four cases, the exon-1/intron-1 border of the
MYC gene, a target area for point mutations in cases of t(8;14) that do not
display rearrangements of the MYC gene, was enzymatically amplified and
sequenced; no point mutations were identified. The indolent behavior of our
six cases, and the finding that the molecular structure of the t(8;14) in
these cases does not follow the pattern of breakpoint sites and point
mutations defined in other histologic subtypes of NHL with this
translocation, suggest that the t(8;14) in these cases is cytogenetically
and molecularly distinct from the t(8;14) seen in high- grade NHLs, and is
relatively ineffectual in terms of MYC deregulation, or that other genetic
elements at these chromosomal sites may be involved. Further analysis of
these tumors may provide insights into MYC deregulation and
BCL2-independent FL.
Volume 79,
Issue 8,
pp. 2124-2130,
04/15/1992
Copyright © 1992 by The American Society of Hematology
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