|
|
 Previous Article | Table of Contents | Next Article 
Regulation of human monocyte DNA synthesis by colony-stimulating factors,
cytokines, and cyclic adenosine monophosphate
DL Cheung and JA Hamilton
University of Melbourne, Department of Medicine, Royal Melbourne Hospital,
Parkville, Australia.
It is reported in this study that a subpopulation of highly purified human
peripheral blood human monocytes can proliferate in response to
colony-stimulating factor-1 (CSF-1), granulocyte-macrophage colony-
stimulating factor (GM-CSF), and interleukin-3 (IL-3). Both GM-CSF and IL-3
synergized with CSF-1 for the induction of DNA synthesis. Given the DNA
synthesis levels attained, we were able to test the effects of certain
cytokines and cyclic adenosine monophosphate (cAMP)-elevating agents, which
have been shown to modulate in vitro human myelopoiesis and murine
macrophage proliferation. The cytokines, interferon-gamma (IFN-gamma),
interleukin-4 (IL-4), and tumor necrosis factor-alpha (TNF- alpha), as well
as cAMP-elevating agents, 8-bromoadenosine 3':5'-cyclic monophosphate
(8BrcAMP), cholera toxin (CT), and prostaglandin E2 (PGE2), suppressed the
monocyte DNA synthesis due to CSF-1. These results parallel those reported
with human bone marrow progenitors, as well as murine macrophage
populations. The cycling human monocyte population could provide a model
cell type to understand the molecular events controlling human
myelopoiesis.
Volume 79,
Issue 8,
pp. 1972-1981,
04/15/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. O. Martinez, S. Gordon, M. Locati, and A. Mantovani
Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression
J. Immunol.,
November 15, 2006;
177(10):
7303 - 7311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. I. L. Clanchy, A. C. Holloway, R. Lari, P. U. Cameron, and J. A. Hamilton
Detection and properties of the human proliferative monocyte subpopulation
J. Leukoc. Biol.,
April 1, 2006;
79(4):
757 - 766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Hamilton, D. Myers, W. Jessup, F. Cochrane, R. Byrne, G. Whitty, and S. Moss
Oxidized LDL Can Induce Macrophage Survival, DNA Synthesis, and Enhanced Proliferative Response to CSF-1 and GM-CSF
Arterioscler. Thromb. Vasc. Biol.,
January 1, 1999;
19(1):
98 - 105.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
