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Multilineage phenotypes of interleukin-3-dependent progenitor cells
AM Ford, LE Healy, CA Bennett, E Navarro, E Spooncer and MF Greaves
Leukaemia Research Fund Centre, Chester Beatty Laboratories, London,
England.
Interleukin-3 (IL-3)-dependent murine FDCP-mix cells have multilineage
differentiation capacity; they are nonleukemic, have a normal karyotype,
and are nonimmortalized. These cells coexpress on their cell surface the
"early" B-lineage marker B220/CD45R and the myeloid marker Mac-1/iC3b
receptor (CR3), transcribe germline T-cell receptor gamma genes, and
express the macrophage lineage growth factor receptor gene c- fms as a
predominant 8.4-kb transcript. They do not detectably express at the stable
mRNA or protein level other lymphoid precursor cell genes including CD2,
TdT, lambda 5, and BP1. Induction of granulocyte/macrophage differentiation
in these cells closes down expression of the lymphoid genes and activates
stable expression of genes specific to the myeloid lineage, including
myeloperoxidase. Expression of the c-fms gene at the mRNA level is
upregulated and the dominant stable transcript is now in the 4.1-kb form
typical of the macrophage lineage. These data provide a plausible
explanation for the coexpression of lymphoid and myeloid lineage markers on
human leukemic cells of stem cell or progenitor cell origin and have
implications for the programming of lineage potential in normal
multipotential hematopoiteic progenitor cells.
Volume 79,
Issue 8,
pp. 1962-1971,
04/15/1992
Copyright © 1992 by The American Society of Hematology
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