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Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated
with the development of the myeloid lineage
E Lagasse and IL Weissman
Department of Pathology, Howard Hughes Medical Institute, Stanford
University School of Medicine, CA 94305.
MRP8 and MRP14 are two S100-like calcium-binding proteins of unknown
function, associated with numbers of human inflammatory disorders. Both
molecules have been described as L1 complex, cystic fibrosis antigen, or p8
and p14. We report here the cloning of mouse MRP8 and MRP14 and their
pattern of expression during hematopoiesis. Mouse MRP8 and MRP14 proteins
share 59% identity with their human counterparts, but they are more
divergent than the other members of the S100 protein family. Mouse MRP
proteins are coexpressed in fetal myeloid progenitors, where they are
detected as early as day 11 of gestation. In fetal liver and yolk sac, MRP+
cell populations increased in number, in association with the development
of the myeloid lineage. In adult mouse, we identified MRP8 and MRP14
proteins in immature myeloid cells of the bone marrow, myeloid cells in the
splenic red pulp and marginal zone, in addition to monocytes and blood
neutrophils. However, MRP expression is lost as cells terminally
differentiate into tissue macrophages. In addition, using
thioglycollate-induced peritoneal inflammatory exudates, we showed that
MRP8 and MRP14 proteins are highly expressed in recruited neutrophils and
monocytes.
Volume 79,
Issue 8,
pp. 1907-1915,
04/15/1992
Copyright © 1992 by The American Society of Hematology
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