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In vivo priming of platelet-activating factor-induced eosinophil chemotaxis
in allergic asthmatic individuals
RA Warringa, HJ Mengelers, PH Kuijper, JA Raaijmakers, PL Bruijnzeel and L Koenderman
Department of Pulmonary Diseases, University Hospital Utrecht, The
Netherlands.
The cytokines granulocyte-macrophage colony-stimulating factor (GM- CSF),
interleukin (IL)-3, and IL-5 are important modulators of eosinophilia and
eosinophil function. Eosinophil chemotaxis is known to be particularly
sensitive for cytokine priming. In the present study, we compared
chemotactic responses of eosinophils derived from peripheral blood of
allergic asthmatics to responses of eosinophils from peripheral blood of
healthy individuals. Eosinophils from allergic asthmatics exhibited a
markedly increased sensitivity in their chemotactic response toward
platelet-activating factor (PAF) compared with eosinophils from normal
donors. In contrast, C5a-induced eosinophil chemotaxis between both groups
was similar. This in vivo- primed phenotype could be mimicked in vitro, by
preincubating eosinophils from peripheral blood of healthy individuals with
picomolar concentrations of either GM-CSF, IL-3, or IL-5. The chemotactic
response of eosinophils derived from the circulation of allergic asthmatic
patients toward GM-CSF was significantly lower compared with the response
of eosinophils of healthy individuals. Our data strongly suggest that
release of cytokines may be an important in vivo priming mechanism for
eosinophils in the circulation of allergic asthmatic patients. Such an in
vivo priming can subsequently result in selective upregulation and
downregulation of chemotactic responses toward various chemoattractants
release in the lung tissue.
Volume 79,
Issue 7,
pp. 1836-1841,
04/01/1992
Copyright © 1992 by The American Society of Hematology
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