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Detection and localization of Epstein-Barr viral genomes in
angioimmunoblastic lymphadenopathy and angioimmunoblastic
lymphadenopathy-like lymphoma
LM Weiss, ES Jaffe, XF Liu, YY Chen, D Shibata and LJ Medeiros
Division of Pathology, City of Hope National Medical Center, Duarte, CA
91010.
We studied 23 cases of angioimmunoblastic lymphadenopathy (AILD) and
AILD-like lymphoma for evidence of Epstein-Barr virus (EBV) using the
polymerase chain reaction (PCR) and in situ hybridization studies. EBV
nucleic acid sequences were found by either PCR or in situ hybridization in
96% of the cases. There was a wide range in the number of EBV-positive
cells among the different cases as detected by in situ hybridization. The
EBV-positive cells most often possessed nuclei of intermediate to large
size. Double-labeling immunohistochemistry/in situ hybridization studies
demonstrated that most of the EBV-positive cells expressed the B-lineage
antigen CD20 (as detected by L26), with a minority of the EBV-positive
cells stained for the T-lineage associated antigen, CD43 (as detected by
Leu 22). The abnormally high amounts of EBV found in AILD and AILD-like
lymphoma may be a reflection of decreased immunocompetence in these
patients. The presence of EBV- positive B cells may explain the presence of
B-cell clones found by others as well as the paradoxical occurrence of
B-cell lymphoma in a primary T-cell lymphoproliferative disorder.
Volume 79,
Issue 7,
pp. 1789-1795,
04/01/1992
Copyright © 1992 by The American Society of Hematology
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