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Acquired immunodeficiency syndrome-associated T-cell lymphoma: evidence for
human immunodeficiency virus type 1-associated T-cell transformation
BG Herndier, BT Shiramizu, NE Jewett, KD Aldape, GR Reyes and MS McGrath
Department of Pathology, University of California, San Francisco.
The majority of lymphomas in the setting of acquired, iatrogenic, or
congenital immunodeficiencies are B-cell lymphoproliferations. We describe
a rare T-cell lymphoma in a fulminantly ill patient infected with human
immunodeficiency virus type 1 (HIV-1). The T-cell nature of the process was
defined genotypically (monoclonal T-cell receptor beta- chain [CT beta]
rearrangement) and phenotypically (CD45RO+, CD4+, CD5+, CD25+, CD8-, CD3-
and negative for a variety of B-cell and monocyte markers). The CD4+, CD25+
(interleukin-2 receptor [IL-2R]) phenotype with production of IL-2 and
IL-2R RNA is analogous to human T- lymphotropic virus type I
(HTLV-I)-associated adult T-cell leukemia/lymphoma (ATLL); however, no
HTLV-1 could be detected. Southern blot analysis did demonstrate
monoclonally integrated HIV-1 within the tumor genome. Furthermore, the
tumor cells were producing HIV p24 antigen as shown by
immunohistochemistry. This is the first case of acquired immunodeficiency
syndrome (AIDS)-associated non- Hodgkin's lymphoma in which HIV-1 infection
may have played a central role in the lymphocyte transformation process.
Volume 79,
Issue 7,
pp. 1768-1774,
04/01/1992
Copyright © 1992 by The American Society of Hematology
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