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CD4+CD7-CD57+ T cells: a new T-lymphocyte subset expanded during human
immunodeficiency virus infection
E Legac, B Autran, H Merle-Beral, C Katlama and P Debre
Departement d'Hematologie, Hopital Pitie-Salpetriere, Paris, France.
CD7 and CD57 are two cell surface molecules related to the differentiation
or functional stages of CD4+ T cells. The CD4+CD7- T cells represent a
minor subset of CD4+ cells in normal individuals and are considered to
contain the normal counterpart of Sezary T cells; the CD4+CD57+ peripheral
blood lymphocytes (PBL) are detectable in long- term renal allograft
recipients. We compared the cell surface expression of these CD7 and CD57
markers on CD4+ T lymphocytes in peripheral blood and lymphoid organs from
normal individuals and human immunodeficiency virus (HIV)-infected
patients. Our results indicate that CD4+CD7- T cells in normal PBL do not
express CD57 and were poorly responsive to anti-CD3 monoclonal antibody
(MoAb), the activation being restored by addition of anti-CD28 MoAb. This
CD4+CD7- cell subset is increased in peripheral blood during HIV infection,
and its progressive expansion mirrors both the absolute and relative
decrease of CD4+ T cells. The lack of CD7 expression is correlated with
CD57 acquisition on CD4+ T cells because CD4+CD7-CD57+ cells represent a
major component of the CD4+CD7- subset in HIV-infected patients. Our
results suggest that the presence and the expansion of CD4+CD7-CD57+ T
lymphocytes, which do not behave as previously defined helper subsets, may
participate to the immune dysfunction observed during HIV infection.
Volume 79,
Issue 7,
pp. 1746-1753,
04/01/1992
Copyright © 1992 by The American Society of Hematology
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