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Implantation and maintenance of functional human bone marrow in SCID-hu
mice
S Kyoizumi, CM Baum, H Kaneshima, JM McCune, EJ Yee and R Namikawa
SyStemix Inc, Palo Alto, CA 94303.
Human fetal bone fragments implanted in the immunodeficient C.B-17
scid/scid (SCID) mouse were shown to sustain active human hematopoiesis in
vivo. Human progenitor cell activity was maintained for as long as 20 weeks
after implantation and was associated with multilineage differentiation in
the engrafted bone. Thus, the bone implants provided stem cells as well as
the microenvironment requisite for their long- term maintenance and
multilineage differentiation. Administration of human erythropoietin (Epo)
stimulated human erythropoiesis in human bone implants. This animal model
may facilitate direct analysis of a wide variety of physiologic and
pathologic conditions of human bone marrow (BM) in vivo.
Volume 79,
Issue 7,
pp. 1704-1711,
04/01/1992
Copyright © 1992 by The American Society of Hematology
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