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IgE in Reed-Sternberg cells of Hodgkin's disease with eosinophilia [see
comments]
M Samoszuk
Pathology Department, University of California, Irvine 92717.
Tissues containing Hodgkin's disease (HD) are frequently infiltrated by
large numbers of eosinophils. Because eosinophils as well as Reed-
Sternberg (RS) cells express membrane receptors (CD23) for IgE, this study
was performed to determine if IgE is present in tissue sections of HD and
to correlate the results, when possible, with serum IgE levels and the
presence of interleukin-5 (IL-5) messenger RNA (mRNA) in RS cells.
Paraffin-embedded, B-5-fixed slices of 13 cases of HD, one case of acquired
immunodeficiency syndrome (AIDS)-related HD, seven cases of benign lymphoid
hyperplasia (including two cases from HD patients), and five cases of
B-cell lymphomas were analyzed by a sensitive immunoperoxidase staining
technique that used a murine monoclonal antibody specific for human IgE. In
the benign hyperplastic lymph nodes and non-Hodgkin's lymphomas, IgE was
generally detectable only in rare plasma cells and in follicular dendritic
cells. In 11 of the 14 cases of HD, including one case of AIDS-related HD,
IgE was readily detectable within RS cells and variants and on the
surrounding cells and connective tissue. These cases also had significant
numbers of eosinophils, and IL-5 mRNA was detectable in three of the cases
that were tested. Serum IgE was moderately elevated in the two serum
specimens from HD patients that were available for analysis. The results of
this study, therefore, indicate that some cases of HD contain abundant
deposits of IgE, which may account for the extensive infiltration by
eosinophils seen in this neoplasm.
Volume 79,
Issue 6,
pp. 1518-1522,
03/15/1992
Copyright © 1992 by The American Society of Hematology
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