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Extensive cross-homology between the long and the short arm of chromosome
16 may explain leukemic inversions and translocations
JG Dauwerse, EA Jumelet, JW Wessels, JJ Saris, A Hagemeijer, GC Beverstock, GJ van Ommen and MH Breuning
Department of Human Genetics, State University Leiden, Sylvius
Laboratories, The Netherlands.
Specific rearrangements of chromosome 16 are well known in acute
nonlymphocytic leukemia with abnormal eosinophils. While mapping cosmids
relative to breakpoints in chromosome 16 in leukemic cells with
fluorescence in situ hybridization (FISH), we have identified three areas
of extensive cross-homology between 16p and 16q. Three cosmids among 99
tested showed two large signals on the short arm and one signal on the long
arm of chromosome 16. A fourth cosmid showed mainly two signals on the
short arm. With the 16p-specific cosmid we can demonstrate that the
breakpoints of a pericentric inversion and a reciprocal (16;16)
translocation, both of which are characteristic for acute leukemia, map to
the most distal of two blocks on the short arm. We suggest that there may
be at least two distinct repetitive elements specific for chromosome 16
interdigitated on 16p. The presence of a similar repeat in the short, as
well as the long arm of the chromosome, may play a role in the origin of
chromosome 16 rearrangements in acute leukemia.
Volume 79,
Issue 5,
pp. 1299-1304,
03/01/1992
Copyright © 1992 by The American Society of Hematology
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