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Interleukin-1 beta (IL-1 beta) expression in human blood mononuclear
phagocytes is differentially regulated by granulocyte-macrophage colony-
stimulating factor (GM-CSF), M-CSF, and IL-3
W Oster, MA Brach, HJ Gruss, R Mertelsmann and F Herrmann
Department of Internal Medicine I, University of Freiburg Medical Center,
Germany.
In this report we show that recombinant human granulocyte-macrophage
colony-stimulating factor (rhGM-CSF) and rh macrophage (M)-CSF induce
accumulation of interleukin-1 beta (IL-1 beta) mRNA in blood-derived
mononuclear phagocytes (MNP). GM-CSF and M-CSF treatment of MNP is also
associated with IL-1 beta secretion. Regulation of GM- and M-CSF- induced
IL-1 beta mRNA expression involves transcriptional and posttranscriptional
mechanisms. However, the action of IL-3 on synthesis of IL-1 beta mRNA
differs from that of other CSFs: While GM- CSF and M-CSF induce binding
activity of the nuclear factor (NF) kappa B, IL-3 treatment of MNP has no
profound effect on NF kappa B binding to DNA. Moreover, IL-3 decreases the
transcription rate of the IL-1 beta gene and has only little effect on
stability of IL-1 beta mRNA, which is increased by GM- and M-CSF. However,
IL-3 enhances M-CSF- induced accumulation of IL-1 beta mRNA by unknown
posttranscriptional means that may relate to an increased expression of
M-CSF receptor (ie, c-fms) mRNA, detectable in mononuclear phagocytes on
exposure to IL-3.
Volume 79,
Issue 5,
pp. 1260-1265,
03/01/1992
Copyright © 1992 by The American Society of Hematology
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